Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

217 questions · 241 findings · 23 reviews

No studies found 65 · 27%GRADE not reported 4 · 1.7%Very low 62 · 25.7%Low 63 · 26.1%Moderate 40 · 16.6%High 7 · 2.9%

Low molecular weight heparin vs UFH

Incidence of recurrent VTE1 after initial treatment (up to 15 days) · patients with venous thromboembolism.

LMWH probably leads to lower incidence of recurrent VTE1 after initial treatment (up to 15 days) compared with UFH (moderate certainty).

1 finding from 1 review

Low molecular weight heparin vs UFH

Recurrent VTE · patients with venous thromboembolism.

LMWH probably leads to lower incidence of recurrent VTE1 (3 months compared with UFH (moderate certainty).

2 findings from 1 review

Low molecular weight heparin vs vitamin K antagonist (VKA)

Recurrent VTE · patients with symptomatic VTE requiring long term treatment (3 months) for symptomatic VTE

LMWH showed no clear difference in incidence of recurrent VTE (treatment duration 3 months) compared with VKA (moderate certainty).

1 finding from 1 review

Low molecular weight heparin vs vitamin K antagonist (VKA)

Major bleeding · patients with symptomatic VTE requiring long term treatment (3 months) for symptomatic VTE

LMWH may leads to lower incidence of major bleeding (treatment duration 3 months) compared with VKA (low certainty).

1 finding from 1 review

Low molecular weight heparin vs vitamin K antagonist (VKA)

Mortality (treatment duration 3 months) · patients with symptomatic VTE requiring long term treatment (3 months) for symptomatic VTE

LMWH showed no clear difference in mortality (treatment duration 3 months) compared with VKA (moderate certainty).

1 finding from 1 review

Intervention not reported

HIT in people undergoing major surgical procedures · people undergoing surgical procedures and treated with UFH or LMWH for prophylaxis of thrombotic events lasting at least 5 days

The intervention may leads to lower HIT in people undergoing major surgical procedures (low certainty).

1 finding from 1 review

Intervention not reported

HIT complicated by venous thromboembolism · people undergoing surgical procedures and treated with UFH or LMWH for prophylaxis of thrombotic events lasting at least 5 days

The intervention may leads to lower HIT complicated by venous thromboembolism (low certainty).

1 finding from 1 review