HALOPERIDOL vs placebo
Relapse · patients with schizophrenia
It is very uncertain whether HALOPERIDOL changes relapse compared with PLACEBO (very low certainty).
1 finding from 1 review
- RR 0.69 [0.55, 0.86]2 studies · 70 participantsVery low
Findings
What do systematic reviews say?
347 questions · 354 findings · 22 reviews
No studies found 100 · 28.2%GRADE not reported 37 · 10.5%Very low 115 · 32.5%Low 64 · 18.1%Moderate 23 · 6.5%High 15 · 4.2%
HALOPERIDOL vs placebo
Leaving the study early · patients with schizophrenia
HALOPERIDOL showed no clear difference in leaving the study early compared with PLACEBO (moderate certainty).
1 finding from 1 review
- RR 0.54 [0.29, 1]8 studies · 304 participantsModerate
HALOPERIDOL vs placebo
Satisfaction with treatment · patients with schizophrenia
1 finding from 1 review
- no estimate extracted0 studies · 0 participantsGRADE not reported
HALOPERIDOL vs placebo
Adverse effects. Specific: movement disorders ‐ parkinsonism · patients with schizophrenia
HALOPERIDOL probably leads to higher adverse effects: Movement disorders ‐ parkinsonism compared with PLACEBO (moderate certainty).
1 finding from 1 review
- RR 5.48 [2.68, 11.22]5 studies · 485 participantsModerate
HALOPERIDOL + PROMETHAZINE vs haloperidol
Tranquil or asleep: Not tranquil or asleep ‐ by 30 mins · people with psychosis‐induced aggression
HALOPERIDOL + PROMETHAZINE leads to lower tranquil or asleep: Not tranquil or asleep ‐ by 30 minutes compared with ANTIPSYCHOTIC ‐ HALOPERIDOL (high certainty).
1 finding from 1 review
- Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes onlyRR 0.65 [0.49, 0.87]1 study · 316 participantsHigh
HALOPERIDOL + PROMETHAZINE vs haloperidol
Global state: Needing restraints or seclusion ‐ by 12 hours · people with psychosis‐induced aggression
HALOPERIDOL + PROMETHAZINE showed no clear difference in global state: Needing restraints or seclusion by 12 hours compared with ANTIPSYCHOTIC ‐ HALOPERIDOL (low certainty).
1 finding from 1 review
- Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes onlyRR 0.83 [0.28, 2.44]1 study · 60 participantsLow
HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM
Sedation score (numerical rating scale of 1 to 6: 0 = anxious, agitated, or restless, 6 = asleep, no response) · people with psychosis‐induced aggression
1 finding from 1 review
- Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes onlyno estimate extracted1 study · 60 participantsLow
HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM
Global state: Needing restraints or seclusion ‐ by 12 hours · people with psychosis‐induced aggression
HALOPERIDOL + PROMETHAZINE led to lower global state: Needing restraints or seclusion ‐ by 12 hours compared with ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM; GRADE not reported.
1 finding from 1 review
- Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes onlyRR 0.24 [0.1, 0.55]1 study · 60 participantsGRADE not reported
HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM
Adverse effects: Specific and serious adverse effect ‐ by 24 hours Central nervous system ‐ excessive sedation · people with psychosis‐induced aggression
HALOPERIDOL + PROMETHAZINE may leads to lower adverse effects: Specific and serious adverse effect ‐ by 24 hours… compared with ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM (low certainty).
1 finding from 1 review
- Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes onlyRR 0.12 [0.03, 0.49]2 studies · 117 participantsLow
HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM
Adverse effect: Specific ‐ Death · people with psychosis‐induced aggression
1 finding from 1 review
- Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes onlyno estimate extracted0 studies · 0 participantsGRADE not reported
HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM
Service outcomes: Not discharged ‐ by 2 weeks · people with psychosis‐induced aggression
1 finding from 1 review
- Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes onlyno estimate extracted0 studies · 0 participantsGRADE not reported
HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM
Aggression · people with psychosis‐induced aggression
1 finding from 1 review
- Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes onlyno estimate extracted1 study · 60 participantsGRADE not reported
HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM
Economic outcomes: Cost of care · people with psychosis‐induced aggression
1 finding from 1 review
- Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes onlyno estimate extracted0 studies · 0 participantsGRADE not reported
HALOPERIDOL + PROMETHAZINE vs haloperidol
Adverse effects: Specific and serious adverse effects by 24 hours (not death) Central nervous system ‐ seizure · people with psychosis‐induced aggression
HALOPERIDOL + PROMETHAZINE showed no clear difference in adverse effects: Specific and serious adverse effects by 24 hours… compared with ANTIPSYCHOTIC ‐ HALOPERIDOL (low certainty).
1 finding from 1 review
- Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes onlyRR 0.95 [0.06, 15.01]1 study · 298 participantsLow
HALOPERIDOL + PROMETHAZINE vs haloperidol
Adverse effect: Specific ‐ Death · people with psychosis‐induced aggression
1 finding from 1 review
- Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes onlyno estimate extracted0 studies · 0 participantsGRADE not reported
HALOPERIDOL + PROMETHAZINE vs haloperidol
Service outcomes: Not discharged ‐ by 2 weeks · people with psychosis‐induced aggression
HALOPERIDOL + PROMETHAZINE showed no clear difference in service outcomes: Not discharged ‐ by 2 weeks compared with ANTIPSYCHOTIC ‐ HALOPERIDOL (high certainty).
1 finding from 1 review
- Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes onlyRR 0.83 [0.64, 1.07]1 study · 310 participantsHigh
HALOPERIDOL + PROMETHAZINE vs haloperidol
Aggression · people with psychosis‐induced aggression
1 finding from 1 review
- Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes onlyno estimate extracted1 study · 60 participantsLow
HALOPERIDOL + PROMETHAZINE vs haloperidol
Economic outcomes: Cost of care · people with psychosis‐induced aggression
1 finding from 1 review
- Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes onlyno estimate extracted0 studies · 0 participantsGRADE not reported
Haloperidol discontinuation vs haloperidol continuation
Global state: 2. Clinically important change (no improvement) ‐ long term · schizophrenia
It is very uncertain whether haloperidol discontinuation changes global state: clinically important change ‒ not improved (CGI) compared with haloperidol continuation (very low certainty).
1 finding from 1 review
- RR 2.06 [1.33, 3.2]1 study · 49 participantsVery low
Haloperidol discontinuation vs haloperidol continuation
Relapse · schizophrenia
It is very uncertain whether haloperidol discontinuation changes global state: relapse: ‒ compared with haloperidol continuation (very low certainty).
1 finding from 1 review
- RR 1.8 [1.18, 2.74]4 studies · 165 participantsVery low