Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

320 questions · 331 findings · 64 reviews · Headline outcomes only

No studies found 44 · 13.3%GRADE not reported 24 · 7.3%Very low 120 · 36.3%Low 90 · 27.2%Moderate 37 · 11.2%High 16 · 4.8%

Aspirin vs placebo

Need for additional pain relief (4 to 8 hours) · women with perineal pain in the early postpartum period

It is very uncertain whether aspirin changes need for additional pain relief (4 to 8 hours) compared with placebo (very low certainty).

1 finding from 1 review

Tafamidis vs placebo

Number of participants experiencing at least one severe adverse event · people with early‐stage TTR‐FAP

It is very uncertain whether tafamidis changes number of participants experiencing at least one severe adverse event compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Mortality In the early postoperative period (≤ 30 days) · participants with hydrocephalus
1 finding from 1 review

Intervention not reported

Mortality Beyond the early postoperative period (> 30 days) · participants with hydrocephalus
1 finding from 1 review

Intervention not reported

Early postoperative non‐thrombotic complications · Individuals with peripheral arterial disease

The intervention showed no clear difference in early postoperative non‐thrombotic complications (high certainty).

1 finding from 1 review