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Evidence found and GRADE certainty

1,888 questions · 2,009 findings · 352 reviews

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No studies found 224 · 11.1%GRADE not reported 265 · 13.2%Very low 551 · 27.4%Low 540 · 26.9%Moderate 311 · 15.5%High 118 · 5.9%

Planned early birth vs expectant management

Length of maternal hospital stay (days) · preterm prelabour rupture of membranes (PPROM)

Planned early birth showed no clear difference in length of hospital stay (maternal) compared with expectant management (moderate certainty).

1 finding from 1 review

Planned early birth vs expectant management

Maternal infectious morbidity (chorioamnionitis and/or endometritis) · women with prelabour rupture of membranes at term (37 weeks' gestation or later)

Planned early birth may leads to lower maternal infectious morbidity (chorioamnionitis and/or endometritis) compared with expectant management (low certainty).

1 finding from 1 review

Planned early birth vs expectant management

Perinatal mortality · women with prelabour rupture of membranes at term (37 weeks' gestation or later)

Planned early birth showed no clear difference in perinatal mortality (stillbirth or neonatal mortality) compared with expectant management (moderate certainty).

1 finding from 1 review

Very early treatment vs expectant management

Severe intraventricular hemorrhage in infants who received neuroimaging · preterm infants

Very early treatment showed no clear difference in severe Intraventricular hemorrhage (grades III and IV) compared with expectant management (moderate certainty).

1 finding from 1 review

Very early treatment vs expectant management

Neurodevelopmental outcomes (moderate/severe cognitive delay at 18 to 24 months) · preterm infants

Very early treatment showed no clear difference in neurodevelopmental outcomes (moderate/severe cognitive delay at 18… compared with expectant management (low certainty).

1 finding from 1 review

Very early treatment vs expectant management

Neurodevelopmental outcomes (moderate/severe motor delay at 18 to 24 months) · preterm infants

Very early treatment showed no clear difference in neurodevelopmental outcomes (moderate/severe motor delay at 18 to 24… compared with expectant management (low certainty).

1 finding from 1 review

Very early treatment vs expectant management

Neurodevelopmental outcomes (moderate/severe language delay at 18 to 24 months) · preterm infants

Very early treatment showed no clear difference in neurodevelopmental outcomes (moderate/severe language delay at 18 to… compared with expectant management (low certainty).

1 finding from 1 review

Very early treatment vs expectant management

Proportion of infants requiring surgical PDA ligation or transcatheter occlusion · preterm infants

Very early treatment showed no clear difference in proportion of infants requiring surgical PDA ligation or… compared with expectant management (moderate certainty).

1 finding from 1 review

Very early treatment vs expectant management

Proportion of infants receiving any pharmacotherapy for a hemodynamically significant PDA · preterm infants

It is very uncertain whether very early treatment changes proportion of infants receiving any pharmacotherapy for a… compared with expectant management (very low certainty).

1 finding from 1 review

Early treatment (two-phase) with headgear vs Early treatment (two-phase) with functional appliance

Incidence of incisal trauma · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)

Early treatment (two-phase) with headgear showed no clear difference in incidence of incisal trauma compared with early treatment (two-phase) with functional appliance; GRADE not reported.

2 findings from 1 review

Early treatment (two-phase) with headgear vs Early treatment (two-phase) with functional appliance

Final ANB · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)

Early treatment (two-phase) with headgear showed no clear difference in final ANB compared with early treatment (two-phase) with functional appliance; GRADE not reported.

2 findings from 1 review

Early treatment (two-phase) with headgear vs Early treatment (two-phase) with functional appliance

PAR score · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)

Early treatment (two-phase) with headgear showed no clear difference in PAR score compared with early treatment (two-phase) with functional appliance; GRADE not reported.

1 finding from 1 review