Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,805 questions · 2,912 findings · 307 reviews · Headline outcomes only

No studies found 706 · 24.2%GRADE not reported 133 · 4.6%Very low 786 · 27%Low 696 · 23.9%Moderate 474 · 16.3%High 117 · 4%

Prism adaptation test with eye muscle surgery vs eye muscle surgery alone

Quality of life measures Measured at 3 years using the IXTQ scores for children, parents, or parent proxies (i.e. parents' perception of their children's quality of life). Scores could range from 0 (worst quality of life) to 100 (best quality of l... · people with intermittent exotropia, aged 5 to 49 years

The review found no eligible studies for this question.

1 finding from 1 review

Lateral rectus recession and medial rectus plication vs lateral rectus recession and medial rectus resection

Stereoacuity at distance Loss of ≥ 2 octaves near stereoacuity Measured using the Preschool Randot test 3 years after surgery · people with intermittent exotropia, aged over 6 years

The review found no eligible studies for this question.

1 finding from 1 review

Lateral rectus recession and medial rectus plication vs lateral rectus recession and medial rectus resection

Quality of life measures Measured at 3 years using the IXTQ scores for children, parents, or parent proxies (i.e. parents' perception of their children's quality of life). Scores could range from 0 (worst quality of life) to 100 (best quality of l... · people with intermittent exotropia, aged over 6 years

The review found no eligible studies for this question.

1 finding from 1 review

Bilateral lateral rectus recession vs lateral rectus recession and medial rectus resection

Motor alignment at distance Change in exotropia control at near fixation, measured from baseline to 3 years using the prism and alternate cover test · people with intermittent exotropia, aged 3 to < 11 years

Bilateral lateral rectus recession showed no clear difference in motor alignment at distance Change in exotropia control at near… compared with unilateral lateral rectus recession with medial rectus resection (moderate certainty).

1 finding from 1 review

Bilateral lateral rectus recession vs lateral rectus recession and medial rectus resection

Quality of life measures Measured at 3 years using the IXTQ scores for children, parents, or parent proxies (i.e. parents' perception of their children's quality of life). Scores could range from 0 (worst quality of life) to 100 (best quality of l... · people with intermittent exotropia, aged 3 to < 11 years
1 finding from 1 review

Intervention not reported

≥ 50% reduction in seizure frequency (children aged 6–18 years) · people with drug‐resistant focal epilepsy

The intervention showed no clear difference in ≥ 50% reduction in seizure frequency (children aged 6–18 years) (moderate certainty).

1 finding from 1 review

iron‐fortified wheat flour with or without other micronutrients added vs fortified wheat flour with same micronutrients (but not iron)

Anaemia · general population of all age groups (including pregnant women) from any country, over two years of age

iron‐fortified wheat flour with or without other micronutrients added may leads to lower anaemia (defined as haemoglobin below WHO cut‐off for age and… compared with wheat flour (no added iron) with the same other micronutrients added (low certainty).

1 finding from 1 review

Wheat flour fortified with iron in combination with other micronutrients vs unfortified wheat flour (no micronutrients added)

Anaemia · general population of all age groups (including pregnant women) from any country, over two years of age

It is very uncertain whether iron‐fortified wheat flour with other micronutrients added changes anaemia (defined as haemoglobin below WHO cut‐off for age and… compared with unfortified wheat flour (no micronutrients added) (very low certainty).

1 finding from 1 review

Pay for performance (P4P) plus existing payment methods vs existing payment methods

Quantity of service provision (continuous) ‐ immunisation rates for patients aged 65 years or older · healthcare providers working in outpatient healthcare settings

It is very uncertain whether pay for performance (P4P) plus existing payment methods changes quantity of service provision (continuous) ‐ immunisation rates for… compared with existing payment methods (very low certainty).

1 finding from 1 review

Intervention not reported

Transepidermal water loss (TEWL) Measured using temperature‐adjusted g/m²/h with the Tewameter TM 300 (Courage + Khazaka, Cologne, Germany) Hahnel 2017: measured at 56 ± 4 days Shishido 2017: measured 15 minutes after wiping the skin with a dry to... · people 60 years of age and older
1 finding from 1 review

Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy

Overall survival for subgroup age 60 years and older glioblastoma · high‐grade glioma

Hypofractionated radiotherapy showed no clear difference in overall survival for subgroup aged ≥ 60 years glioblastoma compared with daily conventionally fractionated radiotherapy (high certainty).

1 finding from 1 review

Combined dietary and physical activity interventions with a caregiver component vs interventions without a caregiver component

Children's percentage of total energy intake from saturated fat Measured by food frequency questionnaire and 24‐hour recall · children aged 4 to 14 years
1 finding from 1 review

Physical activity interventions with a caregiver component vs interventions without a caregiver component

Children's percentage of total energy intake from saturated fat Measured by food frequency questionnaire and 24‐hour recall · children aged 3 to 11 years

The review found no eligible studies for this question.

1 finding from 1 review