Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

82 questions · 83 findings · 60 reviews

No studies found 4 · 4.8%GRADE not reported 9 · 10.8%Very low 25 · 30.1%Low 26 · 31.3%Moderate 12 · 14.5%High 7 · 8.4%

Certolizumab pegol 200 mg sc (with or without MTX) vs placebo (with or without MTX)

Withdrawals due to adverse events · patients with rheumatoid arthritis in adults

Certolizumab pegol 200 mg sc (with or without MTX) leads to higher withdrawals due to adverse events All doses of certolizumab pegol… compared with placebo (with or without MTX) (high certainty).

1 finding from 1 review

Paracetamol vs placebo

Withdrawals due to adverse events · Patients with osteoarthritis of the knee or hip

Paracetamol showed no clear difference in withdrawals due to adverse events 24 weeks compared with placebo (moderate certainty).

1 finding from 1 review

Intermittent/cyclic etidronate 400 mg/day vs placebo

Withdrawals due to adverse events · postmenopausal women with a higher risk for fracturesa

It is very uncertain whether intermittent/cyclic etidronate 400 mg/day changes withdrawals due to adverse events compared with placebo (very low certainty).

1 finding from 1 review

Infliximab 5–10 mg/kg vs placebo

Withdrawals due to adverse events · Patients with active Crohn's disease

The review found no eligible studies for this question.

2 findings from 1 review