Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

18 questions · 18 findings · 7 reviews · Headline outcomes only

No studies found 1 · 5.6%GRADE not reported 6 · 33.3%Very low 9 · 50%Low 2 · 11.1%Moderate 0 · 0%High 0 · 0%

Probiotics vs placebo

Withdrawals due to adverse events · children with chronic constipation without a physical explanation

Probiotic showed no clear difference in withdrawals due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Probiotic + 5‐aminosalicylic acid (5‐ASA) (mesalazine) vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Withdrawals due to adverse events · Patients with quiescent ulcerative colitis

It is very uncertain whether probiotic + 5‐aminosalicylic acid (5‐ASA) (mesalazine) changes withdrawal due to adverse events (12 to 52 weeks) compared with 5‐ASA (mesalazine) (very low certainty).

1 finding from 1 review