Findings

What do systematic reviews say?

4 questions · 4 findings · 4 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 75%Moderate 1 · 25%High 0 · 0%

Perampanel add‐on vs placebo

Withdrawals due to adverse events · people (aged 12 years and over) with drug‐resistant focal epilepsy

Perampanel add‐on may leads to higher treatment withdrawal due to adverse effects compared with placebo (low certainty).

1 finding from 1 review

Perampanel add‐on for drug‐resistant focal epilepsy 2023 · Cochrane Headline outcomes only
RR 2.36 [1.59, 3.51]
7 studies · 2524 participants
Low

Pregabalin vs placebo

Withdrawals due to adverse events · people with drug‐resistant focal epilepsy

Pregabalin probably leads to higher treatment withdrawal due to adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Pregabalin add‐on for drug‐resistant focal epilepsy 2022 · Cochrane Headline outcomes only
RR 2.6 [1.86, 3.64]
9 studies · 2663 participants
Moderate

Benzoyl peroxide vs placebo or no treatment

Adverse effects (side effects; treatment withdrawals) · participants with acne

Benzoyl peroxide may leads to higher withdrawal due to adverse effects (long‐term data) Treatment… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Topical benzoyl peroxide for acne 2020 · Cochrane Headline outcomes only
RR 2.13 [1.55, 2.93]
24 studies · 13744 participants
Low

Calcium channel blockers vs placebo

Withdrawals due to adverse events · patients with Raynaud's phenomenon

Calcium channel blockers showed no clear difference in number of withdrawals due to adverse events Number of participants… compared with placebo (low certainty).

1 finding from 1 review

Calcium channel blockers for primary and secondary Raynaud's phenomenon 2017 · Cochrane Headline outcomes only
RR 1.3 [0.51, 3.33]
2 studies · 63 participants
Low