Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

73 questions · 74 findings · 33 reviews

No studies found 13 · 17.6%GRADE not reported 1 · 1.4%Very low 28 · 37.8%Low 16 · 21.6%Moderate 14 · 18.9%High 2 · 2.7%

Extracorporeal shockwave therapy vs sham

Treatment discontinuation · men with Peyronie's disease (palpable plaque or pain)

It is very uncertain whether extracorporeal shock wave treatment (ESWT) changes discontinuation from treatment compared with sham (very low certainty).

1 finding from 1 review

Potassium paraaminobenzoate vs placebo

Treatment discontinuation · men with acute (maximum of 12 months) Peyronie's disease with no prior treatment and no evidence of calcified plaques (pain during…

It is very uncertain whether potassium paraaminobenzoate changes discontinuation from treatment compared with placebo (very low certainty).

1 finding from 1 review

Penile traction therapy vs no treatment (short‐term)

Treatment discontinuation · men with Peyronie's disease (diagnosis of disease: varying, penile curvature: at least 30 degrees)

It is very uncertain whether penile traction therapy changes discontinuation from treatment compared with no treatment (short‐term) (very low certainty).

1 finding from 1 review

Adalimumab every other week vs placebo

Treatment discontinuation · participants with hidradenitis suppurativa

Adalimumab every other week showed no clear difference in frequency of treatment discontinuation compared with placebo (high certainty).

1 finding from 1 review

Adalimumab weekly vs placebo

Treatment discontinuation · participants with hidradenitis suppurativa

Adalimumab weekly showed no clear difference in frequency of treatment discontinuation compared with placebo (moderate certainty).

1 finding from 1 review

FAE vs MTX

Withdrawals due to adverse events · psoriasis

It is very uncertain whether FAE changes AEs leading to treatment discontinuation compared with MTX (very low certainty).

1 finding from 1 review

Capecitabine vs 5‐FU‐containing regimens

Treatment discontinuation due to toxicity · people with advanced gastric cancer

Capecitabine showed no clear difference in treatment discontinuation due to toxicity compared with 5‐FU‐containing regimens (low certainty).

1 finding from 1 review

Taxane‐platinum‐fluoropyrimidine combinations vs taxane‐platinum (without fluoropyrimidine)

Treatment discontinuation due to toxicity · people with advanced gastric cancer

It is very uncertain whether taxane‐platinum‐fluoropyrimidine combinations changes treatment discontinuation due to toxicity compared with taxane‐platinum (without fluoropyrimidine) (very low certainty).

1 finding from 1 review

S‐1 vs 5‐FU‐containing regimens

Treatment discontinuation due to toxicity · people with advanced gastric cancer

S‐1 showed no clear difference in treatment discontinuation due to toxicity compared with 5‐FU‐containing regimens (high certainty).

1 finding from 1 review

Linezolid vs no linezolid

Antituberculous treatment discontinuationj · drug‐resistant pulmonary tuberculosis

It is very uncertain whether linezolid changes antituberculous treatment discontinuationj compared with no linezolid (very low certainty).

1 finding from 1 review

Intervention not reported

Discontinuation of treatment due to side effects ( · people with or at risk of cardiovascular disease

The intervention probably leads to higher discontinuation of treatment due to side effects ( (moderate certainty).

1 finding from 1 review