Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

41 questions · 42 findings · 29 reviews · Headline outcomes only

No studies found 2 · 4.8%GRADE not reported 2 · 4.8%Very low 6 · 14.3%Low 20 · 47.6%Moderate 9 · 21.4%High 3 · 7.1%

Oestrogen ring vs other regimens

Adverse events (total adverse events) (oestrogen cream vs non‐hormonal lubricant gel) · postmenopausal women with vaginal atrophy

Oestrogen ring showed no clear difference in adverse events (total adverse events) (oestrogen ring vs placebo) compared with other regimens (moderate certainty).

1 finding from 1 review

Oestrogen tablets vs other regimens

Adverse events (total adverse events) (oestrogen cream vs non‐hormonal lubricant gel) · postmenopausal women with vaginal atrophy

Oestrogen tablets showed no clear difference in adverse events (total adverse events) (oestrogen tablets vs placebo) compared with other regimens (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Stem Cell vs placebo or control

Total adverse events · Induction of Remission in Medically Refractory Crohn's Disease

It is very uncertain whether summary of findings table ‐ Stem Cell changes total Adverse Events compared with placebo or Control (very low certainty).

1 finding from 1 review

High‐dose colchicine vs placebo

Total adverse events · acute gout

High‐dose colchicine may leads to higher total adverse events compared with placebo (low certainty).

1 finding from 1 review

Low‐dose colchicine vs placebo

Total adverse events · acute gout

Low‐dose colchicine showed no clear difference in total adverse events compared with placebo (low certainty).

1 finding from 1 review

Monthly pegloticase vs placebo

Total adverse events · participants with tophi in gout

Monthly pegloticase showed no clear difference in total adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Paracetamol vs placebo

Total adverse events: number experiencing 24 weeks · Patients with osteoarthritis of the knee or hip

Paracetamol showed no clear difference in total adverse events: number experiencing 24 weeks compared with placebo (high certainty).

1 finding from 1 review

Antihypertensive drug therapy vs placebo or no treatment

Total serious adverse events · adults (18 years of age or older) with hypertension‐induced left ventricular hypertrophy

It is very uncertain whether antihypertensive therapy changes total serious adverse events compared with placebo or no treatment (very low certainty).

1 finding from 1 review