Findings

What do systematic reviews say?

8 questions · 9 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 44.4%Low 2 · 22.2%Moderate 3 · 33.3%High 0 · 0%

Sudden cardiac death · participants with high risk of sudden cardiac death (primary prevention)

Amiodarone may leads to lower sudden cardiac death compared with placebo or no treatment (low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 0.76 [0.66, 0.88]
17 studies · 8383 participants
Low

Sudden cardiac death · participants with high risk of sudden cardiac death (secondary prevention)

It is very uncertain whether amiodarone changes sudden cardiac death compared with beta blockers (very low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 0.84 [0.55, 1.27]
1 study · 189 participants
Very low

Sudden cardiac death · participants with high risk of sudden cardiac death (secondary prevention)

It is very uncertain whether amiodarone changes sudden cardiac death compared with sotalol (very low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 2.87 [0.32, 25.55]
1 study · 45 participants
Very low

Sudden cardiac death · beta blockers

Amiodarone showed no clear difference in sudden cardiac death compared with beta blockers (low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 0.37 [0.11, 1.22]
2 studies · 342 participants
Low

Sudden cardiac death · participants with high risk of sudden cardiac death (primary prevention)

Amiodarone showed no clear difference in sudden cardiac death compared with other antiarrhythmics (moderate certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 0.44 [0.19, 1]
3 studies · 540 participants
Moderate

Sudden cardiac death · participants with high risk of sudden cardiac death (secondary prevention)

It is very uncertain whether amiodarone changes sudden cardiac death compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 4.32 [0.87, 21.49]
2 studies · 440 participants
Very low

Sudden cardiac death · participants with high risk of sudden cardiac death (secondary prevention)

It is very uncertain whether amiodarone changes sudden cardiac death compared with other antiarrhythmics (very low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 1.4 [0.56, 3.52]
4 studies · 839 participants
Very low

Sudden cardiac death · patients with coronary heart disease

Antibiotics probably leads to higher sudden cardiac death at 24±6 months compared with placebo or no intervention (moderate certainty).

2 findings from 1 review

Antibiotics for secondary prevention of coronary heart disease 2021 · Cochrane Headline outcomes only
RR 1.77 [1.28, 2.44]
2 studies · 4520 participants
Moderate
Antibiotics for secondary prevention of coronary heart disease 2021 · Cochrane Headline outcomes only
RR 1.08 [0.9, 1.31]
2 studies · 4520 participants
Moderate