Findings

What do systematic reviews say?

5 questions · 5 findings · 3 reviews · Tobacco Addiction

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 20%Low 3 · 60%Moderate 0 · 0%High 1 · 20%

Combination vs nicotine replacement therapy monotherapy

Smoking cessation · people who smoke

Combination leads to higher smoking cessation compared with single‐form nicotine replacement therapy (high certainty).

1 finding from 1 review

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.27 [1.17, 1.37]
16 studies · 12169 participants
High

Reduction and pharmacotherapy vs reduction alone

Subgroup: combination NRT; smoking cessation (≥ 6 month · people who smoke

Reduction and pharmacotherapy showed no clear difference in subgroup: combination NRT; smoking cessation (≥ 6 month compared with reduction alone (low certainty).

1 finding from 1 review

Smoking reduction interventions for smoking cessation 2019 · Cochrane Headline outcomes only
RR 1.02 [0.61, 1.69]
3 studies · 1124 participants
Low

Intervention not reported

Combination NRT & bupropion versus placebo Smoking cessation · people who have quit smoking using a cessation intervention

The intervention showed no clear difference in combination NRT & bupropion versus placebo Smoking cessation (low certainty).

1 finding from 1 review

Relapse prevention interventions for smoking cessation 2019 · Cochrane Headline outcomes only
RR 1.18 [0.75, 1.87]
2 studies · 243 participants
Low

Longer vs shorter duration of combination nicotine replacement therapy

Smoking cessation · people who smoke

Longer showed no clear difference in smoking cessation ‐ 6 weeks versus 2 weeks compared with shorter duration of combination nicotine replacement therapy (low certainty).

1 finding from 1 review

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.11 [0.94, 1.31]
1 study · 987 participants
Low

Longer vs shorter duration of combination nicotine replacement therapy

Smoking cessation ‐ 16 weeks versus 8 weeks · people who smoke

It is very uncertain whether longer changes smoking cessation ‐ 16 weeks versus 8 weeks compared with shorter duration of combination nicotine replacement therapy (very low certainty).

1 finding from 1 review

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
RR 0.96 [0.75, 1.23]
1 study · 637 participants
Very low