What do systematic reviews say?

Irinotecan + oxaliplatin vs irinotecan

Irinotecan + oxaliplatin probably leads to higher severe adverse effects compared with irinotecan (moderate certainty).

• Second‐line systemic therapy for metastatic colorectal cancer 2017 · Cochrane Headline outcomes only
  RR 1.22 [1.09, 1.37]
  1 study · 627 participants
  Moderate

Irinotecan‐based regimens vs irinotecan

Irinotecan‐based regimens showed no clear difference in severe adverse effects compared with irinotecan (moderate certainty).

• Second‐line systemic therapy for metastatic colorectal cancer 2017 · Cochrane Headline outcomes only
  RR 1.18 [0.96, 1.45]
  6 studies · 2510 participants
  Moderate

Irinotecan + targeted therapy vs irinotecan

Irinotecan + targeted therapy leads to higher severe adverse effects compared with irinotecan (high certainty).

• Second‐line systemic therapy for metastatic colorectal cancer 2017 · Cochrane Headline outcomes only
  RR 1.44 [1.31, 1.59]
  2 studies · 1704 participants
  High

Sinonasal debridement vs no debridement

The review found no eligible studies for this question.

• Sinonasal debridement versus no debridement for the postoperative care of patients undergoing endoscopic sinus surgery 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Alitretinoin vs placebo

The review found no eligible studies for this question.

• Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Surgery vs botulinum neurotoxin injections

• Interventions for infantile esotropia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 101 participants
  Very low

Bilateral recession vs unilateral recession‐resection

• Interventions for infantile esotropia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 118 participants
  Very low

Triamcinolone acetonide 0.1% cream with occlusive dressing vs clobetasol cream 0.05% cream

The review found no eligible studies for this question.

• Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin

It is very uncertain whether oral ciprofloxacin and inhaled colistin changes adverse effects of antibiotics: severe cough compared with inhaled tobramycin (TNS) (very low certainty).

• Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
  OR 0.32 [0.01, 8.24]
  1 study · 58 participants
  Very low