Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

449 questions · 459 findings · 247 reviews

No studies found 75 · 16.3%GRADE not reported 13 · 2.8%Very low 119 · 25.9%Low 139 · 30.3%Moderate 86 · 18.7%High 27 · 5.9%

Methotrexate vs placebo

Serious adverse events(up to 6 months) · children and young people with JIA

Methotrexate showed no clear difference in serious adverse events(up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Remdesivir and standard care vs placebo or usual care

Serious adverse events at up to day 28 · hospitalised individuals with COVID‐19 (moderate to severe disease)

Remdesivir and standard care showed no clear difference in serious adverse events at up to day 28 compared with standard care (plus/minus placebo) (low certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Serious adverse events within 6 months · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

It is very uncertain whether casirivimab/imdevimab changes serious adverse events within 6 months compared with placebo (very low certainty).

1 finding from 1 review

Paracetamol vs placebo

Serious adverse events Up to 12 weeks' · Patients with acute low‐back pain

Paracetamol showed no clear difference in serious adverse events Up to 12 weeks' compared with placebo (moderate certainty).

1 finding from 1 review

Rotarix vs placebo

Serious adverse events: intussusception · children

Rotarix showed no clear difference in serious adverse events: intussusception compared with placebo (low certainty).

3 findings from 1 review

RotaTeq vs placebo

Serious adverse events: intussusception · children

RotaTeq showed no clear difference in serious adverse events: intussusception compared with placebo (low certainty).

3 findings from 1 review