Findings

What do systematic reviews say?

8 questions · 8 findings · 3 reviews · Airways

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No studies found 3 · 37.5%GRADE not reported 0 · 0%Very low 1 · 12.5%Low 4 · 50%Moderate 0 · 0%High 0 · 0%

Quinolone vs macrolides

Quality of life Drug resistance/microbial sensitivity Serious adverse events Lung function Hospitalisations Adverse events/side effects Number of participants colonised with P aeruginosa · patients with chronic obstructive pulmonary disease

The review found no eligible studies for this question.

1 finding from 1 review

Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Quinolone vs tetracycline

The review found no eligible studies for this question.

1 finding from 1 review

Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fibrinolytics vs placebo

Serious adverse events · adult parapneumonic effusions and empyema

Fibrinolytics showed no clear difference in serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Intra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult… 2019 · Cochrane Headline outcomes only
OR 1.28 [0.36, 4.57]
9 studies · 935 participants
Low

Fluoroquinolones vs amoxicillin

Serious adverse events · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis

1 finding from 1 review

Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 83 participants
Low

Macrolides vs tetracycline

The review found no eligible studies for this question.

1 finding from 1 review

Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Polymyxins vs aminoglycosides

Serious adverse events · adults with bronchiectasis

1 finding from 1 review

Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Alteplase vs urokinase

Serious adverse events · adult parapneumonic effusions and empyema

Alteplase may leads to higher serious adverse events compared with urokinase (low certainty).

1 finding from 1 review

Intra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult… 2019 · Cochrane Headline outcomes only
OR 5.61 [1.16, 27.11]
1 study · 99 participants
Low

Streptokinase vs urokinase

Serious adverse events · adult parapneumonic effusions and empyema

Streptokinase showed no clear difference in serious adverse events compared with urokinase (low certainty).

1 finding from 1 review

Intra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult… 2019 · Cochrane Headline outcomes only
OR 5.43 [0.25, 118.96]
1 study · 50 participants
Low