What do systematic reviews say?

Hysterectomy (simple or radical) with radiotherapy vs Radiotherapy alone

Hysterectomy (simple or radical) with radiotherapy may leads to higher severe/serious adverse events compared with radiotherapy alone (low certainty).

• Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer 2022 · Cochrane Headline outcomes only
  OR 4
  2 studies · 374 participants
  Low

Hysterectomy (simple or radical) with chemoradiotherapy vs chemoradiotherapy alone

The review found no eligible studies for this question.

• Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

External beam radiotherapy (EBRT) plus transarterial chemoembolisation (TACE) vs TACE alone

The review found no eligible studies for this question.

• External beam radiotherapy for unresectable hepatocellular carcinoma 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Tenofovir‐based antiviral combination regimens vs placebo or tenofovir alone or non‐tenofovir‐based antiviral regimens

It is very uncertain whether tenofovir‐based antiviral combination regimens changes proportion of infants with serious adverse events ( compared with placebo or tenofovir alone or non‐tenofovir‐based antiviral regimens (very low certainty).

• Antivirals for prevention of hepatitis B virus mother‐to‐child transmission in human immunodeficiency virus positive… 2023 · Cochrane Headline outcomes only
  RR 1.76 [1.27, 2.43]
  1 study · 132 participants
  Very low

Tenofovir‐based antiviral combination regimens vs placebo or tenofovir alone or non‐tenofovir‐based antiviral regimens

It is very uncertain whether tenofovir‐based antiviral combination regimens changes proportion of mothers with serious adverse events ( compared with placebo or tenofovir alone or non‐tenofovir‐based antiviral regimens (very low certainty).

• Antivirals for prevention of hepatitis B virus mother‐to‐child transmission in human immunodeficiency virus positive… 2023 · Cochrane Headline outcomes only
  RR 0.9 [0.62, 1.32]
  2 studies · 270 participants
  Very low

Single‐dose, preoperative MMC‐EMDA vs TURBT alone

It is very uncertain whether single‐dose, preoperative MMC‐EMDA changes serious adverse events compared with TURBT alone (very low certainty).

• Intravesical electromotive drug administration for non‐muscle invasive bladder cancer 2017 · Cochrane Headline outcomes only
  RR 1.74 [0.52, 5.77]
  1 study · 233 participants
  Very low

Colchicine vs placebo or usual care

• Colchicine for the treatment of COVID‐19 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 4412 participants
  Moderate