Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

182 questions · 183 findings · 59 reviews

No studies found 71 · 38.8%GRADE not reported 11 · 6%Very low 57 · 31.1%Low 24 · 13.1%Moderate 15 · 8.2%High 5 · 2.7%

Plasma‐derived C1 esterase inhibitor vs placebo or active control

Serious adverse events (during · children or adults with Types I or II HAE

It is very uncertain whether plasma‐derived C1 esterase inhibitor changes serious adverse events (during compared with placebo or active control (very low certainty).

1 finding from 1 review

Recombinant human C1 esterase inhibitor vs placebo or active control

Serious adverse events (during · children or adults with Types I or II HAE

It is very uncertain whether recombinant human C1 esterase inhibitor changes serious adverse events (during compared with placebo or active control (very low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events (number) · people with acute pancreatitis
1 finding from 1 review