Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

182 questions · 183 findings · 59 reviews

No studies found 71 · 38.8%GRADE not reported 11 · 6%Very low 57 · 31.1%Low 24 · 13.1%Moderate 15 · 8.2%High 5 · 2.7%

Mesalamine vs placebo

Serious adverse events · Patients with collagenous colitis

Mesalamine showed no clear difference in serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Budesonide vs placebo

Serious adverse events · Patients with collagenous colitis

It is very uncertain whether budesonide changes serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Serious adverse events · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

High‐dose corticosteroids probably leads to higher serious adverse events compared with moderate‐dose or no corticosteroids (moderate certainty).

1 finding from 1 review

Ascorbic acid vs placebo

Serious adverse events · people with fatigue in peripheral neuropathy

Ascorbic acid showed no clear difference in serious adverse events compared with placebo (moderate certainty).

1 finding from 1 review