Methadone vs placebo
Participants experiencing anyserious adverseevents · adults with chronic neuropathic pain
1 finding from 1 review
- no estimate extractedStudies not reportedVery low
Findings
What do systematic reviews say?
10 questions · 10 findings · 9 reviews · Pain, Palliative and Supportive Care
No studies found 6 · 60%GRADE not reported 0 · 0%Very low 2 · 20%Low 1 · 10%Moderate 1 · 10%High 0 · 0%
Methylnaltrexone vs placebo
Serious adverse eventsi · people receiving palliative care irrespective of whether they had cancer with opioid‐induced bowel dysfunction
Methylnaltrexone may leads to lower serious adverse eventsi compared with placebo (low certainty).
1 finding from 1 review
- Mu‐opioid antagonists for opioid‐induced bowel dysfunction in people with cancer and people receiving palliative care 2022 · Cochrane Headline outcomes onlyRR 0.59 [0.38, 0.93]2 studies · 364 participantsLow
Lower‐dose methylnaltrexone vs higher dose
Serious adverse events · people receiving palliative care irrespective of whether they had cancer with opioid‐induced bowel dysfunction
The review found no eligible studies for this question.
1 finding from 1 review
- Mu‐opioid antagonists for opioid‐induced bowel dysfunction in people with cancer and people receiving palliative care 2022 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
High‐dose corticosteroids vs moderate‐dose or no corticosteroids
Serious adverse events · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)
High‐dose corticosteroids probably leads to higher serious adverse events compared with moderate‐dose or no corticosteroids (moderate certainty).
1 finding from 1 review
- Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes onlyRR 8.02 [1.03, 62.37]2 studies · 77 participantsModerate
Intervention not reported
Serious AE · adults with migraine headache ‐ moderate or severe pain
The review found no eligible studies for this question.
1 finding from 1 review
- Ibuprofen with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Intervention not reported
Serious AE · adults with migraine headache ‐ moderate or severe pain
The review found no eligible studies for this question.
1 finding from 1 review
- Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Intervention not reported
Serious AE · migraine headache ‐ moderate or severe pain
The review found no eligible studies for this question.
1 finding from 1 review
- Aspirin with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Intervention not reported
Serious AE · adults with migraine headache ‐ moderate or severe pain
The review found no eligible studies for this question.
1 finding from 1 review
- Diclofenac with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Naproxen 500 mg or 825 mg vs placebo
Serious AE · migraine headache ‐ moderate or severe pain
The review found no eligible studies for this question.
1 finding from 1 review
- Naproxen with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Intervention not reported
Participants with a serious adverse event · adults with acute postoperative pain
1 finding from 1 review
- Single dose dipyrone (metamizole) for acute postoperative pain in adults 2016 · Cochrane Headline outcomes onlyno estimate extracted5 studies · 288 participantsVery low