Findings

What do systematic reviews say?

6 questions · 6 findings · 4 reviews · Drugs and Alcohol

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 33.3%Moderate 0 · 0%High 4 · 66.7%

Full opioid agonists vs different full opioid agonists or partial opioid agonists (methadone versus buprenorphine)

Retention [ · pharmaceutical opioid dependent people

Full opioid agonists may leads to higher retention compared with different full opioid agonists or partial opioid agonists (methadone… (low certainty).

1 finding from 1 review

Opioid agonist treatment for people who are dependent on pharmaceutical opioids 2022 · Cochrane Headline outcomes only
RR 1.21 [1.02, 1.43]
4 studies · 379 participants
Low

Dihydrocodeine vs methadone

Retention in treatment · individuals dependent on illicit opiates

Dihydrocodeine showed no clear difference in treatment retention compared with methadone (low certainty).

1 finding from 1 review

Dihydrocodeine for detoxification and maintenance treatment in individuals with opiate use disorders 2020 · Cochrane Headline outcomes only
RR 1.04 [0.94, 1.16]
1 study · 204 participants
Low

Intervention not reported

Retention in treatment · People with opioid dependence.

The intervention leads to lower retention in treatment (high certainty).

1 finding from 1 review

Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence 2014 · Cochrane Headline outcomes only
RR 0.83 [0.73, 0.95]
11 studies · 1391 participants
High

Intervention not reported

Retention in treatment · People with opioid dependence.

The intervention leads to higher retention in treatment (high certainty).

1 finding from 1 review

Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence 2014 · Cochrane Headline outcomes only
RR 1.82 [1.15, 2.9]
5 studies · 1001 participants
High

Intervention not reported

Retention in treatment ‐ New studies · patients with opioid dependence

The intervention leads to higher retention in treatment ‐ New studies (high certainty).

1 finding from 1 review

Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence 2009 · Cochrane Headline outcomes only
RR 4.44 [3.26, 6.04]
4 studies · 750 participants
High

Intervention not reported

Retention in treatment ‐ Old studies (pre 2000) objective · patients with opioid dependence

The intervention leads to higher retention in treatment ‐ Old studies (pre 2000) objective (high certainty).

1 finding from 1 review

Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence 2009 · Cochrane Headline outcomes only
RR 3.05 [1.75, 5.35]
3 studies · 505 participants
High