Cochrane · systematic review · CD002207
Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence
Mattick, RP, Breen, C, Kimber, J, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Drugs and AlcoholAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 6 · 75%High 2 · 25%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings: comparison between flexible‐dose methadone and buprenorphine
Population: People with opioid dependence.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Retention in treatment | RR 0.83 [0.73, 0.95] | 11 studies · 1391 participants | High |
Morphine‐positive urines | no estimate extracted | 8 studies · 1027 participants | Moderate |
Self‐reported heroin use | no estimate extracted | 4 studies · 501 participants | Moderate |
Cocaine‐positive urines | SMD 0.1 | 6 studies · 919 participants | Moderate |
Benzodiazepine‐positive urines | SMD 0.05 | 6 studies · 859 participants | Moderate |
Summary of findings for the comparison between high‐dose buprenorphine and placebo
Population: People with opioid dependence.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Retention in treatment | RR 1.82 [1.15, 2.9] | 5 studies · 1001 participants | High |
Morphine‐positive urines | no estimate extracted | 3 studies · 729 participants | Moderate |
Benzodiazepine‐positive urines | no estimate extracted | 2 studies · 336 participants | Moderate |