Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

25 questions · 27 findings · 12 reviews · Musculoskeletal

No studies found 11 · 40.7%GRADE not reported 0 · 0%Very low 2 · 7.4%Low 9 · 33.3%Moderate 3 · 11.1%High 2 · 7.4%

Antidepressants vs placebo

Quality of life (EuroQol, scale −0.11 to 1.0 where a score of 1.0 indicates perfect health) between 0 and 14 weeks · predominantly knee osteoarthritis

Antidepressant probably leads to higher quality of life (EuroQol, scale −0.11 to 1.0 where a score of 1.0… compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

SF‐36 social function. Domain of SF‐36 considered representative of quality of life: mental health domain largely covered by depression and anxiety above: scale of 0‐100. Higher score indicated improved social function. Mean duration of · people with chronic hip, knee or hip and knee osteoarthritis
1 finding from 1 review

Intervention not reported

Quality of life · people with neurological conditions1

The review found no eligible studies for this question.

1 finding from 1 review