Findings

What do systematic reviews say?

16 questions · 16 findings · 8 reviews · Dementia and Cognitive Improvement

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No studies found 9 · 56.3%GRADE not reported 2 · 12.5%Very low 2 · 12.5%Low 0 · 0%Moderate 3 · 18.8%High 0 · 0%

Aromatherapy vs placebo or control

Quality of life · people with dementia

1 finding from 1 review

Aromatherapy for dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 134 participants
Very low

Trazodone vs placebo

Quality of life · sleep disturbances in dementia

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacotherapies for sleep disturbances in dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Orexin antagonists vs placebo

Quality of life · sleep disturbances in dementia

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacotherapies for sleep disturbances in dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Melatonin vs placebo

Quality of life · sleep disturbances in dementia

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacotherapies for sleep disturbances in dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Souvenaid vs placebo

Quality of life · People with mild Alzheimer's disease

1 finding from 1 review

Souvenaid for Alzheimer's disease 2020 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

B vitamins vs placebo

Quality of life · MCI

1 finding from 1 review

Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 138 participants
Moderate

Souvenaid vs placebo

Quality of life, · Apathy in people with mild‐to‐moderate Alzheimer's disease

1 finding from 1 review

Souvenaid for Alzheimer's disease 2020 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Other NSAIDs vs placebo

Health‐related quality of life · cognitively healthy people in late life

The review found no eligible studies for this question.

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Celecoxib vs placebo

Health‐related quality of life · older people with age‐related memory loss

The review found no eligible studies for this question.

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Aspirin vs placebo

Health‐related quality of life · cognitively healthy people in late life

The review found no eligible studies for this question.

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin E vs placebo

Quality of life ‐ not measured · MCI

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin E + vitamin C vs placebo

Quality of life ‐ not measured · MCI

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Trazodone vs placebo

Carer burden, well‐being or quality of life · sleep disturbances in dementia

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacotherapies for sleep disturbances in dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Donepezil 10 mg/day vs placebo

Quality of life of participants (change from baseline at 26 weeks) · people with Alzheimer's disease

1 finding from 1 review

Donepezil for dementia due to Alzheimer's disease 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 815 participants
Moderate

Antihypertensive drug therapy vs placebo

Quality of life measured via Sickness Impact Profile, PGWB Positive well‐being, and EuroQoL Current Health Range of · participants without prior cerebrovascular disease for prevention of cognitive impairment and dementia

1 finding from 1 review

Pharmacological treatment of hypertension in people without prior cerebrovascular disease for the prevention of… 2021 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 15795 participants
Very low

Rivastigmine vs placebo

Quality of life of patients or carers (measured using NPI‐D carer distress scale (change from baseline at 24 weeks) · Apathy in people with mild‐to‐moderate Alzheimer's disease

1 finding from 1 review

Rivastigmine for Alzheimer's disease 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 529 participants
Moderate