Cochrane · systematic review · CD011679
Souvenaid for Alzheimer's disease
Burckhardt, M, Watzke, S, Wienke, A, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Dementia and Cognitive ImprovementAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
16
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 5 · 23.8%Very low 0 · 0%Low 0 · 0%Moderate 16 · 76.2%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Souvenaid compared to placebo for MCI/prodromal AD
Population: People with MCI/prodromal AD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of dementia Souvenaid vs placebo | RR 1.09 [0.82, 1.43] | 1 study · 311 participants | Moderate Downgraded: imprecision |
Cognition (global cognitive function) Souvenaid vs placebo | no estimate extracted | 1 study · 311 participants | Moderate Downgraded: imprecision |
Memory (specific cognitive function) Souvenaid vs placebo | no estimate extracted | 1 study · 311 participants | Moderate Downgraded: imprecision |
Executive function (specific cognitive function) Souvenaid vs placebo | no estimate extracted | 1 study · 311 participants | Moderate Downgraded: imprecision |
Functional outcome (e.g. activities of daily living) Souvenaid vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Combined cognitive‐functional outcome Souvenaid vs placebo | no estimate extracted | 1 study · 311 participants | Moderate Downgraded: imprecision |
Any adverse event Souvenaid vs placebo | RR 0.99 [0.91, 1.08] | 1 study · 309 participants | Moderate Downgraded: imprecision |
Souvenaid compared to placebo for mild Alzheimer's disease dementia
Population: People with mild Alzheimer's disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognition (global cognitive function) Souvenaid vs placebo | no estimate extracted | 1 study · 259 participants | Moderate Downgraded: imprecision |
Memory (specific cognitive function) Souvenaid vs placebo | no estimate extracted | 1 study · 259 participants | Moderate Downgraded: imprecision |
Executive function (specific cognitive function) Souvenaid vs placebo | no estimate extracted | 1 study · 259 participants | Moderate Downgraded: imprecision |
Functional outcome (activities of daily living) Souvenaid vs placebo | no estimate extracted | 1 study · 259 participants | Moderate Downgraded: imprecision |
Quality of life Souvenaid vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Combined cognitive‐functional outcome Souvenaid vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Any adverse events Souvenaid vs placebo | RR 0.86 [0.69, 1.07] | 1 study · 258 participants | Moderate Downgraded: imprecision |
Souvenaid compared to placebo for mild‐to‐moderate Alzheimer's dementia
Population: People with mild‐to‐moderate Alzheimer's dementia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognition (global cognitive function) Souvenaid vs placebo | no estimate extracted | 1 study · 527 participants | Moderate Downgraded: imprecision |
Memory (specific cognitive function) Souvenaid vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Executive function (specific cognitive function) Souvenaid vs placebo | no estimate extracted | 1 study · 527 participants | Moderate Downgraded: imprecision |
Activities of daily living (functional outcome) Souvenaid vs placebo | no estimate extracted | 1 study · 527 participants | Moderate Downgraded: imprecision |
Quality of life, Souvenaid vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Combined cognitive‐functional outcome Souvenaid vs placebo | no estimate extracted | 1 study · 527 participants | Moderate Downgraded: imprecision |
Any adverse events Souvenaid vs placebo | RR 0.9 [0.78, 1.03] | 1 study · 524 participants | Moderate Downgraded: imprecision |