Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

40 questions · 40 findings · 11 reviews · Cystic Fibrosis and Genetic Disorders

No studies found 18 · 45%GRADE not reported 2 · 5%Very low 2 · 5%Low 11 · 27.5%Moderate 7 · 17.5%High 0 · 0%

Summary of findings ‐ triple therapy: elexacaftor‐tezacaftor‐ivacaftor vs control (ivacaftor alone or tezacaftor plus ivacaftor)

Quality of life: total score · adults and children aged 12 years and over with cystic fibrosis and either F508del/gating variant or F508del/residual function genotype

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings ‐ triple therapy: elexacaftor‐tezacaftor‐ivacaftor/deutivacaftor vs control

Quality of life: total score · adults with cystic fibrosis and either F508del/MF or F508del/F508del genotype

The review found no eligible studies for this question.

1 finding from 1 review