What do systematic reviews say?

Oral hydroxyurea vs placebo

The review found no eligible studies for this question.

• Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral nutritional supplements vs placebo

The review found no eligible studies for this question.

• Nutritional interventions for treating foot ulcers in people with diabetes 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral valproic acid vs placebo

• Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
  no estimate extracted
  28 participants
  Moderate

Oral phenylbutyrate vs placebo

The review found no eligible studies for this question.

• Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Avoralstat vs placebo

• Interventions for the long‐term prevention of hereditary angioedema attacks 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 93 participants
  Moderate

Toothache vs No toothache

The umbrella review reported that toothache has a high impact on oral health-related quality of life.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Dental (tooth) agenesis vs No dental agenesis

The umbrella review reported insufficient scientific evidence to support an association between dental agenesis and oral health-related quality of life.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported
• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  tooth agenesis does not have enough scientific evidence to support a relationship between OHRQoL [41]. No articles were found that had evaluated children and adolescent. Only one was found to have a greater impact in…
  Studies not reported
  GRADE not reported

Malocclusion vs No malocclusion

The umbrella review reported that malocclusion negatively affects oral health-related quality of life.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Periodontal disease (severe periodontitis) vs No or less severe periodontal disease

The umbrella review reported worse oral health-related quality-of-life scores with severe periodontitis.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Dental caries or greater caries severity vs No or less severe dental caries

The umbrella review reported worse oral health-related quality of life with greater caries severity.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Completed orthodontic treatment vs No previous or incomplete orthodontic treatment

The umbrella review reported better oral health-related quality of life after completed orthodontic treatment.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Older age vs Younger adults (population mean age <=33.4 years)

The abstract reports older age is associated with worse OHRQoL, but the body notes the evidence on age is limited and conflicting (narrative synthesis; no pooled estimate or GRADE rating).

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  Worse oral health status, older age, female sex and worse socioeconomic status were significantly associated with worse OHRQoL. [Body: the influence of religion and age on OHRQoL is unknown; Biological data such as…
  Studies not reported
  GRADE not reported
• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Female sex vs Male sex

The abstract reports female sex is associated with worse OHRQoL, but the conclusion states the impact of gender was not clarified (narrative synthesis; no pooled estimate or GRADE rating).

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  Worse oral health status, older age, female sex and worse socioeconomic status were significantly associated with worse OHRQoL. [Conclusion: gender and skin color did not have their level of impact clarified.]
  Studies not reported
  GRADE not reported
• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Bruxism vs No bruxism

Bruxism was not shown to impact OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  While dental erosion and bruxism have not been shown to impact the quality of life of adolescents [26]. Bruxism does not impact quality of life in children and adolescentes [33].
  Studies not reported
  GRADE not reported
• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Dental erosion vs No dental erosion

The umbrella review reported that dental erosion has not been shown to affect oral health-related quality of life.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported
• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  While dental erosion and bruxism have not been shown to impact the quality of life of adolescents [26].
  Studies not reported
  GRADE not reported

Favorable socioeconomic and family environment vs Less favorable socioeconomic and family environment

The umbrella review reported better oral health-related quality of life with favorable housing, parental education, income, family environment, and access to dental care.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Temporomandibular disorder vs No temporomandibular disorder

Temporomandibular disorder is associated with worse OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  dental caries, malocclusion [9, 26-30], TMD [9], dental trauma (TDI) [32, 34, 35], poor brushing [36], toothache [26], periodontal disease [34] and edentulism [9] negatively affect the quality of life of adolescents.
  Studies not reported
  GRADE not reported
• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Irregular brushing vs Regular brushing

The umbrella review reported that irregular brushing negatively affects oral health-related quality of life.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Missing teeth / tooth loss vs No tooth loss or edentulism

The umbrella review reported that tooth loss and edentulism negatively affect oral health-related quality of life.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Uncomplicated traumatic dental injury vs No traumatic dental injury

The umbrella review reported no negative oral health-related quality-of-life impact from uncomplicated traumatic dental injuries.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported