Findings

What do systematic reviews say?

725 questions · 738 findings · 261 reviews

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No studies found 403 · 54.6%GRADE not reported 61 · 8.3%Very low 124 · 16.8%Low 101 · 13.7%Moderate 45 · 6.1%High 4 · 0.5%

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

Participant satisfaction or quality of life · People with temporomandibular disorders (TMD)

Occlusal splint led to lower participant satisfaction or quality of life compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.

1 finding from 1 review

Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes
Short term (1 month) · Mixed TMD
MD -7.56 [-14.50, -0.63]
2 studies · 75 participants
GRADE not reported

Occlusal splint vs acupuncture

Participant satisfaction or quality of life · People with temporomandibular disorders (TMD)

Occlusal splint showed no clear difference in participant satisfaction or quality of life compared with acupuncture; GRADE not reported.

1 finding from 1 review

Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes
Short term (1 month) · Mixed TMD
MD 0.80 [-7.36, 8.96]
1 study · 30 participants
GRADE not reported

Occlusal splint vs Another occlusal splint with a different mechanism of action

Participant satisfaction or quality of life · People with temporomandibular disorders (TMD)

Occlusal splint led to lower participant satisfaction or quality of life compared with another occlusal splint with a different mechanism of action; GRADE not reported.

1 finding from 1 review

Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes
Short term (3 months) · Mixed TMD
MD -2.29 [-3.13, -1.45]
1 study · 40 participants
GRADE not reported

Occlusal splint vs Behavioural therapy (counselling, CBT, relaxation, self-care management)

Participant satisfaction or quality of life · People with temporomandibular disorders (TMD)

Occlusal splint showed no clear difference in participant satisfaction or quality of life compared with behavioural therapy (counselling, CBT, relaxation, self-care…; GRADE not reported.

1 finding from 1 review

Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes
Short term (1 month) · Mixed TMD
MD -1.42 [-15.78, 12.94]
2 studies · 73 participants
GRADE not reported

mHealth education intervention vs usual care

Health‐related quality of life Analysis 1.4 · adults with heart failure

1 finding from 1 review

mHealth education interventions in heart failure 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 942 participants
Very low

Combined HBO and perioperative antibiotics prior to dental implant therapy vs antibiotics alone

Adverse effects (including quality of life) · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)

1 finding from 1 review

Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes
1 year
This comparison was only made in 1 study which reported no serious adverse events associated with HBO therapy. Quality of life measures (oral status, functioning, satisfaction) showed emotional functioning and pain…
1 study · 26 participants
Very low

Case management vs usual care

Quality of life (MLHFQ): from 0 to 105 · adults with heart failure

1 finding from 1 review

Disease management interventions for heart failure 2019 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 1595 participants
Very low

Analgesic (any: NSAID, paracetamol, local anaesthetic or opioid) vs placebo or control

Quality of life or participant satisfaction · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
Reported narratively by 2 studies (Wang 2012: SF-36 and SAS - significant reduction in SF-36 bodily pain at 30 days vs baseline, no significant between-group differences; Minor 2009: STAI and PANAS - no significant…
2 studies
GRADE not reported

NSAID (systemic) vs paracetamol

Quality of life or participant satisfaction · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
No studies in this comparison reported this outcome.
0 studies
No studies found

Topical NSAID (ketoprofen lysinate mouthwash, 160 mg) vs Topical NSAID (benzidamine hydrochloride mouthwash, 22.5 mg)

Quality of life or participant satisfaction · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
The study did not report this outcome.
0 studies
No studies found

Ibuprofen taken pre-emptively (about 1 hour before treatment) vs Ibuprofen taken post-treatment

Quality of life or participant satisfaction · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
No studies in this comparison reported this outcome.
0 studies
No studies found

Topical NSAID (ketoprofen chewing gum) vs Local anaesthetic (benzocaine chewing gum)

Quality of life or participant satisfaction · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
The study did not report this outcome.
0 studies
No studies found

Individual TF‐CBT vs EMDR

Quality of life: 1. General quality of life · Adults with co‐morbid PTSD and SMI

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for post‐traumatic stress disorder (PTSD) in people with severe mental illness 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

EMDR vs inactive control (usual care care, attention control, waitlist)

Quality of life: 1. General quality of life · Adults with co‐morbid PTSD and SMI

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for post‐traumatic stress disorder (PTSD) in people with severe mental illness 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Light vibrational forces (LVF) vs Conventional orthodontic appliance treatment

Oral health-related quality of life · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances

1 finding from 1 review

Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes
Katchooi 2018 (unclear risk of bias): light vibrational forces had no statistically significant (P>0.05) effect on OHRQoL when used with orthodontic aligners.
1 study · 27 participants
GRADE not reported

Summary of findings table ‐ Protein vs standard diet

Health‐related quality of life ‐ not reported · patients (> 65 years) following hip fracture; patients with a recent stroke

The review found no eligible studies for this question.

1 finding from 1 review

Nutritional interventions for preventing and treating pressure ulcers 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Energy, protein and micronutrients vs standard diet

Health‐related quality of life ‐ not reported · long‐term care patients; inpatients without dehydration with energy intake by tube feeding; patients with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Nutritional interventions for preventing and treating pressure ulcers 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Protein, arginine, zinc and antioxidants vs standard diet or placebo

Health‐related quality of life ‐ not reported · residents of long‐term care (≥ 65 years) with pressure ulcers; inpatients with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Nutritional interventions for preventing and treating pressure ulcers 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Arginine and micronutrients vs standard diet

Health‐related quality of life ‐ not reported · malnourished patients with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Nutritional interventions for preventing and treating pressure ulcers 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Collagen vs standard diet or placebo

Health‐related quality of life ‐ not reported · adults with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Nutritional interventions for preventing and treating pressure ulcers 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found