What do systematic reviews say?

Endovascular revascularisation vs no therapy

The review found no eligible studies for this question.

• Endovascular revascularisation versus conservative management for intermittent claudication 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Early vs deferred AST

• Early versus deferred standard androgen suppression therapy for advanced hormone‐sensitive prostate cancer 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 285 participants
  Moderate

Fluoxetine vs light therapy

• Second‐generation antidepressants for treatment of seasonal affective disorder 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 96 participants
  Low

Commercial mouthcare system (Biotene Oral Balance / Xerostom) vs Usual care or CMC-based control

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  Ship 2007 reported xerostomia-related quality of life; no usable comparative data.
  1 study
  GRADE not reported

Commercial mouthcare system (Biotene Oral Balance / Xerostom) vs Bioxtra mouthcare system

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  No difference between systems for overall xerostomia-related quality of life (15-item survey). Bioxtra rated better for taste; no difference for mouth 'feel'. Trial likely underpowered.
  1 study · 20 participants
  GRADE not reported

Augmentation of current antidepressant (SSRI/SNRI) with mirtazapine (30 mg/d) vs augmentation of current antidepressant (various) with placebo

• Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 447 participants
  High

Electrical stimulation vs drug therapy

The review found no eligible studies for this question.

• Electrical stimulation with non‐implanted devices for stress urinary incontinence in women 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

GnRH‐a + raloxifene vs GnRH‐a ± placebo

• Add‐back therapy with GnRH analogues for uterine fibroids 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 74 participants
  Low

GnRH‐a + tibolone vs GnRH‐a ± placebo

• Add‐back therapy with GnRH analogues for uterine fibroids 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 110 participants
  Low

Physical activity vs usual care

• Physical activity interventions for disease‐related physical and mental health during and following treatment in… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 230 participants
  Moderate

Subthreshold vs standard macular photocoagulation

The review found no eligible studies for this question.

• Monotherapy laser photocoagulation for diabetic macular oedema 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Laser photocoagulation vs no intervention

The review found no eligible studies for this question.

• Monotherapy laser photocoagulation for diabetic macular oedema 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings table ‐ Cognitive rehabilitation vs inactive control

• Cognitive rehabilitation for people with mild to moderate dementia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 853 participants
  Moderate

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

Occlusal splint led to lower participant satisfaction or quality of life compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.

• Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes

  Short term (1 month) · Mixed TMD
  MD -7.56 [-14.50, -0.63]
  2 studies · 75 participants
  GRADE not reported

Occlusal splint vs Behavioural therapy (counselling, CBT, relaxation, self-care management)

Occlusal splint showed no clear difference in participant satisfaction or quality of life compared with behavioural therapy (counselling, CBT, relaxation, self-care…; GRADE not reported.

• Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes

  Short term (1 month) · Mixed TMD
  MD -1.42 [-15.78, 12.94]
  2 studies · 73 participants
  GRADE not reported

Steroid implant vs standard‐of‐care therapy

• Corticosteroid implants for chronic non‐infectious uveitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Moderate

Postoperative MMC‐EMDA induction vs MMC‐PD induction therapy

The review found no eligible studies for this question.

• Intravesical electromotive drug administration for non‐muscle invasive bladder cancer 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Postoperative MMC‐EMDA with sequential BCG induction and maintenance vs postoperative BCG induction and maintenance therapy

The review found no eligible studies for this question.

• Intravesical electromotive drug administration for non‐muscle invasive bladder cancer 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Postoperative MMC‐EMDA induction vs postoperative BCG induction therapy

The review found no eligible studies for this question.

• Intravesical electromotive drug administration for non‐muscle invasive bladder cancer 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Sertraline vs cognitive behavioural therapy

• Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 118 participants
  Moderate