Findings

What do systematic reviews say?

112 questions · 112 findings · 64 reviews

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No studies found 62 · 55.4%GRADE not reported 7 · 6.3%Very low 22 · 19.6%Low 15 · 13.4%Moderate 5 · 4.5%High 1 · 0.9%

Surgical vs conservative interventions

Health‐related quality of life (physical) · adults (aged ≥ 16 years) with acute middle third clavicle fractures

1 finding from 1 review

Surgical versus conservative interventions for treating fractures of the middle third of the clavicle 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 321 participants
Low

Ethinyl estradiol 35 μg + cyproterone acetate 2 mg vs ethinyl estradiol 30 μg + desogestrel 0.15 mg

Change in health‐related quality of life (HRQOL) ‐ not measured · patients with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Combined HBO and perioperative antibiotics prior to dental implant therapy vs antibiotics alone

Adverse effects (including quality of life) · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)

1 finding from 1 review

Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes
1 year
This comparison was only made in 1 study which reported no serious adverse events associated with HBO therapy. Quality of life measures (oral status, functioning, satisfaction) showed emotional functioning and pain…
1 study · 26 participants
Very low

Hydrocortisone vs placebo

Quality of life at 3 months ‐ not measured · adults (aged 18 and older) exposed to a traumatic event

The review found no eligible studies for this question.

1 finding from 1 review

Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: bevacizumab vs placebo

Quality of life · people previously treated with radiosurgery or fractionated radiotherapy to the brain or head and neck region with a diagnosis of brain…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Quality of life · General practitioners/family doctors involved in the management of patients with low back pain

The review found no eligible studies for this question.

1 finding from 1 review

Professional interventions for general practitioners on the management of musculoskeletal conditions 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Quality of life · General practitioners/family doctors involved in the management of patients with osteoarthritis

1 finding from 1 review

Professional interventions for general practitioners on the management of musculoskeletal conditions 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

Quality of life · General practitioners/family doctors involved in the management of patients with shoulder pain

The review found no eligible studies for this question.

1 finding from 1 review

Professional interventions for general practitioners on the management of musculoskeletal conditions 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Quality of life · General practitioners/family doctors involved in the management of patients with other musculoskeletal conditions

The review found no eligible studies for this question.

1 finding from 1 review

Professional interventions for general practitioners on the management of musculoskeletal conditions 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Quality of life · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

1 finding from 1 review

Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
Baseline and 6 months
no estimate extracted
1 study · 49 participants
GRADE not reported

naltrexone vs placebo

Quality of life ‐ not measured · participants with cholestatic pruritus (CP)

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pruritus in adult palliative care patients 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants (trazodone 200 mg/day) vs placebo

QoL · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

1 finding from 1 review

Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
short-term (up to 3 months)
SoF1. Change in QoL short-term (mean Beck Depression Inventory, 0-63, lower better): this single study narratively reported that both intervention and placebo participants were less depressed at trial completion, but…
1 study · 37 participants
Very low

Eplerenone (25 mg daily) vs placebo

Improvements in quality of life measures · boys with DMD and left ventricular ejection fraction 45% or more

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Augmentation of current antidepressant (SSRI) with busiprone (20 mg/d to 60 mg/d) vs placebo plus antidepressant

Quality of life ‐ not measured · treatment‐resistant depression in adults

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Augmentation of current antidepressant (SSRI) with ziprasidone (40 mg/d to 160 mg/d) vs augmentation of current antidepressant (SSRI) with placebo or continue on SSRI monotherapy

Quality of life ‐ not measured · treatment‐resistant depression in adults

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Idebenone vs placebo

Improvements in quality of life measures · boys (aged 8 to 16 years old) with subclinical cardiomyopathy in DMD

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Timer watch plus standard urotherapy vs urotherapy alone

Quality of life measurements · children aged 5 to 14 years with overactive bladder and at least one episode of daytime urinary incontinence per week

The review found no eligible studies for this question.

1 finding from 1 review

Conservative interventions for treating functional daytime urinary incontinence in children 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral dehydroepiandrosterone vs placebo

Secondary outcome: Dermatology Quality of Life measure · patients with cutaneous disease in systemic lupus erythematosus

1 finding from 1 review

Interventions for cutaneous disease in systemic lupus erythematosus 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Growth hormone (0.23 mg/kg/week for DMD and 0.07 mg/kg/week in BMD SC injection) vs placebo

Improvements in quality of life measures · people with DMD or BMD (ages not stated)

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Erythrocytapheresis vs phlebotomy

Health‐related quality of life beyond one year · people with hereditary haemochromatosis

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hereditary haemochromatosis 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found