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Evidence found and GRADE certainty

23 questions · 23 findings · 2 reviews · Skin

No studies found 2 · 8.7%GRADE not reported 1 · 4.3%Very low 3 · 13%Low 6 · 26.1%Moderate 4 · 17.4%High 7 · 30.4%

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Proportion of participants with adverse event · Participants with rosacea

Minocycline 45 mg showed no clear difference in proportion of participants with adverse event compared with minocycline 45 mg + azelaic acid gel (low certainty).

1 finding from 1 review

Azelaic acid vs placebo

Proportion of participants with adverse event · Participants with rosacea
1 finding from 1 review

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Proportion of participants with adverse event · Participants with rosacea

Low dose isotretinoin 0.3 mg/kg showed no clear difference in proportion of participants with adverse event compared with doxycycline 50‐100 mg (high certainty).

1 finding from 1 review

Metronidazole vs placebo

Proportion of participants with adverse event · Participants with rosacea

Metronidazole showed no clear difference in proportion of participants with adverse event compared with placebo (high certainty).

1 finding from 1 review

Topical ivermectin vs topical metronidazole

Proportion of participants with adverse event · Participants with rosacea

Topical ivermectin showed no clear difference in proportion of participants with adverse event compared with topical metronidazole (moderate certainty).

1 finding from 1 review

Ciclosporin ophthalmic emulsion 0.05% vs artificial tears

Proportion of participants with adverse event · Participants with ocular rosacea

Ciclosporin ophthalmic emulsion 0.05% showed no clear difference in proportion of participants with adverse event compared with artificial tears (low certainty).

1 finding from 1 review

Clindamycin phosphate 1.2% + tretinoin 0.025% gel vs placebo

Proportion of participants with adverse event · Participants with rosacea

Clindamycin phosphate 1.2% + tretinoin 0.025% gel probably leads to higher proportion of participants with adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Tetracycline vs placebo

Proportion of participants with adverse event · Participants with rosacea

Tetracycline showed no clear difference in proportion of participants with adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Azithromycin vs doxycycline

Proportion of participants with adverse event · Participants with rosacea

It is very uncertain whether azithromycin changes proportion of participants with adverse event compared with doxycycline 100 mg (very low certainty).

1 finding from 1 review