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Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

9 questions · 9 findings · 6 reviews · Headline outcomes only

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No studies found 1 · 11.1%GRADE not reported 0 · 0%Very low 6 · 66.7%Low 0 · 0%Moderate 1 · 11.1%High 1 · 11.1%

Acupuncture vs no intervention

Proportion of participants with 1 or more serious adverse events · chronic hepatitis B

The review found no eligible studies for this question.

1 finding from 1 review

Methylphenidate vs placebo or no intervention

Proportion of participants with one or more serious adverse events · Children and adolescents with ADHD

It is very uncertain whether methylphenidate changes proportion of participants with one or more serious adverse events compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Intervention not reported

Proportion of participants with 1 or more serious adverse events at maximum · adults with compensated or decompensated advanced chronic liver disease

It is very uncertain whether the intervention changes proportion of participants with 1 or more serious adverse events at… (very low certainty).

1 finding from 1 review

Methylphenidate vs placebo or no intervention

Adverse events considered non‐serious (penicillin versus doxycycline) · Children and adolescents with ADHD

It is very uncertain whether methylphenidate changes proportion of participants with one or more adverse events… compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Vitamin D vs placebo

Proportion of participants with one or more serious adverse events due to any cause · children and adults with predominantly mild to moderate asthma

Summary of findings table ‐ Vitamin D showed no clear difference in proportion of participants with one or more serious adverse events… compared with placebo (high certainty).

1 finding from 1 review

Cycled inhaled tobramycin vs culture‐based TNS

Adverse effects of antibiotics: proportion of participants with one or more serious adverse event · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Cycled inhaled tobramycin (TNS) probably leads to lower adverse effects of antibiotics: proportion of participants with one… compared with culture‐based TNS (moderate certainty).

1 finding from 1 review

Radix Sophorae flavescentis vs placebo or no intervention

Non‐serious adverse events Maximum · chronic hepatitis B

It is very uncertain whether radix Sophorae flavescentis changes proportion of participants with 1 or more adverse events considered… compared with no intervention or placebo (very low certainty).

1 finding from 1 review

Acupuncture vs no intervention

Non‐serious adverse events Maximum · chronic hepatitis B

It is very uncertain whether acupuncture changes proportion of participants with 1 or more adverse events considered… compared with no intervention (very low certainty).

1 finding from 1 review