Findings

What do systematic reviews say?

7 questions · 7 findings · 6 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 7 · 100%Moderate 0 · 0%High 0 · 0%

NIPPV vs NCPAP

Pneumothorax · )

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in pneumothorax compared with nasal continuous positive airway pressure (NCPAP) (by population) (low certainty).

1 finding from 1 review

Early nasal intermittent positive pressure ventilation (NIPPV) versus early nasal continuous positive airway pressure… 2023 · Cochrane Headline outcomes only
RR 0.92 [0.6, 1.41]
16 studies · 1674 participants
Low

Bubble vs ventilator or Infant Flow Driver nasal continuous positive airway pressure (CPAP)

Pneumothorax · preterm infants receiving nasal CPAP

Bubble showed no clear difference in pneumothorax compared with ventilator or Infant Flow Driver nasal continuous positive airway… (low certainty).

1 finding from 1 review

Bubble devices versus other pressure sources for nasal continuous positive airway pressure in preterm infants 2023 · Cochrane Headline outcomes only
RR 0.73 [0.4, 1.34]
14 studies · 1340 participants
Low

Early vs late continuous positive airway pressure (CPAP)

Pulmonary air leak defined as pneumothorax · preterm infants with respiratory distress for initial respiratory support

Early showed no clear difference in air leak (pneumothorax) compared with late continuous positive airway pressure (CPAP) (low certainty).

1 finding from 1 review

Early versus delayed continuous positive airway pressure (CPAP) for respiratory distress in preterm infants 2020 · Cochrane Headline outcomes only
RR 1.09 [0.39, 3.04]
3 studies · 98 participants
Low

Continuous positive airway pressure (CPAP) vs supplemental oxygen

Pneumothorax · preterm infants with respiratory distress for initial respiratory support

CPAP may leads to higher pneumothorax occurring after allocation compared with supplemental oxygen (low certainty).

1 finding from 1 review

Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants 2020 · Cochrane Headline outcomes only
RR 2.91 [1.38, 6.13]
4 studies · 270 participants
Low

Prophylactic CPAP vs mechanical ventilation

Pulmonary air leak defined as pneumothorax · preterm infants

Prophylactic CPAP showed no clear difference in pulmonary air leak defined as pneumothorax compared with mechanical ventilation (low certainty).

1 finding from 1 review

Prophylactic or very early initiation of continuous positive airway pressure (CPAP) for preterm infants 2021 · Cochrane Headline outcomes only
RR 1.24 [0.91, 1.69]
3 studies · 2357 participants
Low

Prophylactic or very early CPAP vs supportive care

Pulmonary air leak defined as pneumothorax · preterm infants

Prophylactic or very early CPAP showed no clear difference in pulmonary air leak defined as pneumothorax compared with supportive care (low certainty).

1 finding from 1 review

Prophylactic or very early initiation of continuous positive airway pressure (CPAP) for preterm infants 2021 · Cochrane Headline outcomes only
RR 0.75 [0.35, 1.16]
3 studies · 568 participants
Low

Mask vs prongs

Pneumothorax · preterm infants receiving nasal CPAP

Mask showed no clear difference in pneumothorax compared with prongs (low certainty).

1 finding from 1 review

Masks versus prongs as interfaces for nasal continuous positive airway pressure in preterm infants 2022 · Cochrane Headline outcomes only
RR 0.93 [0.45, 1.93]
5 studies · 625 participants
Low