Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

54 questions · 55 findings · 21 reviews

No studies found 7 · 12.7%GRADE not reported 17 · 30.9%Very low 11 · 20%Low 14 · 25.5%Moderate 3 · 5.5%High 3 · 5.5%

Sulodexide (heparin plus dermatan sulphate chains) vs placebo

Days to resolution of pain / epithelialization; number of aphthae per month · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Prednisone (oral, commencing 25 mg with phased dose reduction over 2 months) vs placebo

Days to resolution of pain / epithelialization; number of aphthae per month · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
  • Femiano 2003 (high risk of bias) reports days to resolution of pain and days to epithelialization of aphthae at 1 month, and number of aphthae per month after the first and second months; data presented as…
    1 study · 20 participants
    GRADE not reported

Sodium hypochlorite (NaOCl), 2.5% to 5.25% vs Sodium hypochlorite 1%

Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review