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It is very uncertain whether heparin changes heparin‐induced thrombocytopaenia compared with normal saline solution locking (very low certainty).
Heparin showed no clear difference in major bleeding events: unfractionated heparin compared with placebo (low certainty).
Heparin showed no clear difference in major bleeding events: all heparin compared with placebo (low certainty).
It is very uncertain whether heparin changes readmissions to intensive care: all heparin compared with placebo (very low certainty).
Heparin may leads to lower occlusion of CVC (combining participant, and catheter as unit of… compared with normal saline solution locking (low certainty).
It is very uncertain whether heparin changes CVC‐related bloodstream infections (positive microbiological… compared with normal saline solution locking (very low certainty).
It is very uncertain whether heparin changes mortality compared with normal saline solution locking (very low certainty).
It is very uncertain whether heparin changes haemorrhage from any site compared with normal saline solution locking (very low certainty).
It is very uncertain whether heparin changes any Intraventricular Haemorrage (IVH) compared with placebo/no treatment (very low certainty).
Heparin showed no clear difference in severe IVH compared with placebo/no treatment (low certainty).
Heparin showed no clear difference in neonatal mortality (all‐cause) compared with placebo/no treatment (low certainty).
Heparin showed no clear difference in all‐cause mortality compared with placebo (low certainty).
Heparin may leads to lower incidence of myocardial infarction compared with placebo (low certainty).
It is very uncertain whether heparin changes recurrent angina compared with placebo (very low certainty).
Heparin showed no clear difference in incidence of revascularization procedures compared with placebo (low certainty).
Heparin showed no clear difference in major hemorrhage compared with placebo (low certainty).