Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

268 questions · 274 findings · 96 reviews

No studies found 24 · 8.8%GRADE not reported 11 · 4%Very low 27 · 9.9%Low 66 · 24.1%Moderate 96 · 35%High 50 · 18.2%

Docetaxel vs non‐docetaxel‐containing regimens

Overall survival ‐ Substitutive comparisons · people with advanced gastric cancer

Docetaxel showed no clear difference in overall survival ‐ Substitutive comparisons compared with non‐docetaxel‐containing regimens (moderate certainty).

1 finding from 1 review

Sodium thiosulfate vs no otoprotective intervention

Overall survival with intravenous platinum (i.e. mortality/number of participants deceased) · children with cancer treated with platinum‐based therapy

Sodium thiosulfate showed no clear difference in overall survival with intravenous platinum (i.e. mortality/number of… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Next‐generation ALK inhibitor vs crizotinib

Progression‐free survival · advanced anaplastic lymphoma kinase (ALK)‐rearranged non‐small cell lung cancer

Next‐generation ALK inhibitor leads to lower progression‐free survival: overall population compared with crizotinib (high certainty).

1 finding from 1 review

Physical activity vs usual care

Overall survival (time interval between enrolment in the study and death of the person from any cause) · adults with non‐advanced colorectal cancer treated surgically or with neoadjuvant or adjuvant therapy, or both

The review found no eligible studies for this question.

1 finding from 1 review