Findings

What do systematic reviews say?

12 questions · 14 findings · 5 reviews · Headline outcomes only

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No studies found 1 · 7.1%GRADE not reported 5 · 35.7%Very low 2 · 14.3%Low 1 · 7.1%Moderate 3 · 21.4%High 2 · 14.3%

Thrombopoietin mimetics vs placebo or usual care

Number of platelet transfusions per participant up to 30 days from study entry · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

1 finding from 1 review

Alternatives, and adjuncts, to prophylactic platelet transfusion for people with haematological malignancies… 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 120 participants
Very low

Intervention not reported

Number of platelet transfusions ‐ not reported · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

The review found no eligible studies for this question.

1 finding from 1 review

Alternatives, and adjuncts, to prophylactic platelet transfusion for people with haematological malignancies… 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion

Number of platelet transfusions per participant up to 30 days from study entry · patients with haematological disorders undergoing myelosuppressive chemotherapy or stem cell transplantation

1 finding from 1 review

A therapeutic‐only versus prophylactic platelet transfusion strategy for preventing bleeding in patients with… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 801 participants
Moderate

Prophylactic platelet transfusion vs platelet‐poor plasma

Number of platelet transfusions per participant up to 30 days from study entry · People with a haematological disorder

1 finding from 1 review

Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after… 2012 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 1 participants
Very low

Prophylactic platelet transfusion vs non prophylactic or therapeutic platelet transfusion

Number of platelet transfusions per participant up to 30 days from study entry · People with a haematological disorder

1 finding from 1 review

Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after… 2012 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 85 participants
Moderate

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

Number of platelet transfusions per participant up to 30 days from study entry · People with a haematological disorder

2 findings from 2 reviews · compare the 2 reviews

Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 333 participants
Low
Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after… 2012 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 333 participants
Moderate

Prophylactic platelet transfusions with low‐dose schedule vs high‐dose schedule

Number of platelet transfusions per participant up to 30 days from study entry · People with a haematological disorder

1 finding from 1 review

Different doses of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders… 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 849 participants
GRADE not reported

Prophylactic platelet transfusions with high‐dose schedule vs standard‐dose strategies

Number of platelet transfusions per participant up to 30 days from study entry · People with a haematological disorder

1 finding from 1 review

Different doses of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders… 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1005 participants
GRADE not reported

Prophylactic platelet transfusions with low‐dose schedule vs prophylactic platelet transfusions with standard‐dose schedule

Number of platelet transfusions per participant up to 30 days from study entry · People with a haematological disorder

1 finding from 1 review

Different doses of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders… 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1070 participants
GRADE not reported

Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule

Bleeding Number of days with significant bleeding ‐ Low dosage platelet transfusions versus standard dosage platelet transfusions · People with a haematological disorder

1 finding from 1 review

Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after… 2012 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 3 participants
GRADE not reported

Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule

Bleeding: Number of days with significant bleeding ‐ High dosage platelet transfusions versus standard dosage platelet transfusions · People with a haematological disorder

1 finding from 1 review

Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after… 2012 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 2 participants
GRADE not reported

Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule

Bleeding: Numbers of patients with at least one significant bleeding event · People with a haematological disorder

Prophylactic platelet transfusion with one dose schedule showed no clear difference in bleeding Number of participants with a significant bleeding event ‐… compared with prophylactic platelet transfusions with another dose schedule (high certainty).

2 findings from 1 review

Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after… 2012 · Cochrane Headline outcomes only
RR 1.02 [0.93, 1.11]
2 studies · 951 participants
High
Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after… 2012 · Cochrane Headline outcomes only
RR 1.04 [0.95, 1.13]
3 studies · 1070 participants
High