Findings

What do systematic reviews say?

12 questions · 14 findings · 5 reviews

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No studies found 1 · 7.1%GRADE not reported 5 · 35.7%Very low 2 · 14.3%Low 1 · 7.1%Moderate 3 · 21.4%High 2 · 14.3%

Prophylactic platelet transfusion vs non prophylactic or therapeutic platelet transfusion

Number of platelet transfusions per participant up to 30 days from study entry · People with a haematological disorder

1 finding from 1 review

Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after… 2012 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 85 participants
Moderate

Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion

Number of platelet transfusions per participant up to 30 days from study entry · patients with haematological disorders undergoing myelosuppressive chemotherapy or stem cell transplantation

1 finding from 1 review

A therapeutic‐only versus prophylactic platelet transfusion strategy for preventing bleeding in patients with… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 801 participants
Moderate

Prophylactic platelet transfusions with low‐dose schedule vs prophylactic platelet transfusions with standard‐dose schedule

Number of platelet transfusions per participant up to 30 days from study entry · People with a haematological disorder

1 finding from 1 review

Different doses of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders… 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1070 participants
GRADE not reported

Prophylactic platelet transfusion vs platelet‐poor plasma

Number of platelet transfusions per participant up to 30 days from study entry · People with a haematological disorder

1 finding from 1 review

Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after… 2012 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 1 participants
Very low

Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule

Bleeding Number of days with significant bleeding ‐ Low dosage platelet transfusions versus standard dosage platelet transfusions · People with a haematological disorder

1 finding from 1 review

Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after… 2012 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 3 participants
GRADE not reported

Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule

Bleeding: Number of days with significant bleeding ‐ High dosage platelet transfusions versus standard dosage platelet transfusions · People with a haematological disorder

1 finding from 1 review

Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after… 2012 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 2 participants
GRADE not reported

Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule

Bleeding: Numbers of patients with at least one significant bleeding event · People with a haematological disorder

Prophylactic platelet transfusion with one dose schedule showed no clear difference in bleeding Number of participants with a significant bleeding event ‐… compared with prophylactic platelet transfusions with another dose schedule (high certainty).

2 findings from 1 review

Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after… 2012 · Cochrane Headline outcomes only
RR 1.02 [0.93, 1.11]
2 studies · 951 participants
High
Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after… 2012 · Cochrane Headline outcomes only
RR 1.04 [0.95, 1.13]
3 studies · 1070 participants
High

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

Number of platelet transfusions per participant up to 30 days from study entry · People with a haematological disorder

2 findings from 2 reviews · compare the 2 reviews

Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 333 participants
Low
Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after… 2012 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 333 participants
Moderate

Prophylactic platelet transfusions with low‐dose schedule vs high‐dose schedule

Number of platelet transfusions per participant up to 30 days from study entry · People with a haematological disorder

1 finding from 1 review

Different doses of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders… 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 849 participants
GRADE not reported

Prophylactic platelet transfusions with high‐dose schedule vs standard‐dose strategies

Number of platelet transfusions per participant up to 30 days from study entry · People with a haematological disorder

1 finding from 1 review

Different doses of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders… 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1005 participants
GRADE not reported

Thrombopoietin mimetics vs placebo or usual care

Number of platelet transfusions per participant up to 30 days from study entry · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

1 finding from 1 review

Alternatives, and adjuncts, to prophylactic platelet transfusion for people with haematological malignancies… 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 120 participants
Very low

Intervention not reported

Number of platelet transfusions ‐ not reported · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

The review found no eligible studies for this question.

1 finding from 1 review

Alternatives, and adjuncts, to prophylactic platelet transfusion for people with haematological malignancies… 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found