Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews · Pain, Palliative and Supportive Care

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 2 · 66.7%Moderate 0 · 0%High 0 · 0%

Intravenous diclofenac vs NSAIDs

Number of participants experiencing any serious adverse events · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries

Intravenous diclofenac showed no clear difference in number of participants experiencing a serious adverse event compared with another NSAID (low certainty).

1 finding from 1 review

Single‐dose intravenous diclofenac for acute postoperative pain in adults 2018 · Cochrane Headline outcomes only
RR 0.94 [0.13, 6.6]
4 studies · 423 participants
Low

Intravenous diclofenac vs placebo

Number of participants experiencing any serious adverse events · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries

Intravenous diclofenac showed no clear difference in number of participants experiencing a serious adverse event compared with placebo (low certainty).

1 finding from 1 review

Single‐dose intravenous diclofenac for acute postoperative pain in adults 2018 · Cochrane Headline outcomes only
RR 1 [0.15, 7.02]
5 studies · 472 participants
Low

Summary of Findings Table ‐ Ibuprofen 300 mg vs paracetamol

Number of participants experiencing any serious adverse events · health problem or population

1 finding from 1 review

Single‐dose intravenous ibuprofen for acute postoperative pain in adults 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
Very low