Findings

What do systematic reviews say?

6 questions · 6 findings · 3 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 16.7%Moderate 4 · 66.7%High 1 · 16.7%

Benzodiazepines vs placebo

Withdrawals due to adverse events · adults with panic disorder

Benzodiazepines may leads to higher number of dropouts due to adverse effects compared with placebo (low certainty).

1 finding from 1 review

Benzodiazepines versus placebo for panic disorder in adults 2019 · Cochrane Headline outcomes only
RR 1.58 [1.16, 2.15]
14 studies · 3263 participants
Low

Tricyclic antidepressants vs placebo

Withdrawals due to adverse events · adults with panic disorder

Tricyclic antidepressants probably leads to higher number of dropouts due to adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 1.97 [1.33, 2.91]
10 studies · 1641 participants
Moderate

Selective serotonin reuptake inhibitors vs placebo

Withdrawals due to adverse events · adults with panic disorder

Selective serotonin reuptake inhibitors probably leads to higher number of dropouts due to adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 1.45 [1.16, 1.81]
22 studies · 4131 participants
Moderate

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Withdrawals due to adverse events · adults with panic disorder

Serotonin‐norepinephrine reuptake inhibitors showed no clear difference in number of dropouts due to adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 1.49 [0.92, 2.4]
4 studies · 1531 participants
Moderate

Antidepressants vs placebo

Withdrawals due to adverse events · adults with panic disorder

Antidepressants probably leads to higher number of dropouts due to adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 1.49 [1.25, 1.78]
33 studies · 7688 participants
Moderate

Brexpiprazole vs antidepressive agents

Adverse effects (dropouts) · participants of any age with a primary diagnosis of major depressive disorder

Brexpiprazole leads to higher number of dropouts due to adverse effects at 8 weeks compared with antidepressive agents (high certainty).

1 finding from 1 review

Brexpiprazole versus placebo or other antidepressive agents for treating depression 2023 · Cochrane Headline outcomes only
OR 2.88 [1.37, 6.05]
6 studies · 2472 participants
High