Cochrane · systematic review · CD010677
Benzodiazepines versus placebo for panic disorder in adults
Breilmann, J, Girlanda, F, Guaiana, G, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Common Mental DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 33.3%Low 4 · 66.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Benzodiazepines compared to placebo for adults with panic disorder
Population: adults with panic disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Response Benzodiazepines vs placebo | RR 1.65 [1.39, 1.96] | 16 studies · 2476 participants | Low Downgraded: risk of bias |
Total number of dropouts Benzodiazepines vs placebo | RR 0.5 [0.39, 0.64] | 21 studies · 3558 participants | Low Downgraded: risk of bias |
Remission Benzodiazepines vs placebo | RR 1.61 [1.38, 1.88] | 15 studies · 2907 participants | Low Downgraded: risk of bias |
Panic symptoms ‐ endpoint score Benzodiazepines vs placebo | no estimate extracted | 7 studies · 1489 participants | Very low Downgraded: risk of bias |
Panic symptoms ‐ mean change Benzodiazepines vs placebo | no estimate extracted | 4 studies · 719 participants | Very low Downgraded: risk of bias |
Number of dropouts due to adverse effects Benzodiazepines vs placebo | RR 1.58 [1.16, 2.15] | 14 studies · 3263 participants | Low Downgraded: risk of bias |