Findings

What do systematic reviews say?

6 questions · 6 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 16.7%Low 5 · 83.3%Moderate 0 · 0%High 0 · 0%

Withdrawals due to adverse events · adults with panic disorder

Benzodiazepines may leads to higher number of dropouts due to adverse effects compared with placebo (low certainty).

1 finding from 1 review

Benzodiazepines versus placebo for panic disorder in adults 2019 · Cochrane Headline outcomes only
RR 1.58 [1.16, 2.15]
14 studies · 3263 participants
Low

Withdrawals due to adverse events · adults with panic disorder

TCAs may leads to higher number of dropouts due to adverse effects compared with benzodiazepines (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 2.1 [1.13, 3.93]
2 studies · 848 participants
Low

Withdrawals due to adverse events · adults with panic disorder

It is very uncertain whether SSRIs changes number of dropouts due to adverse effects compared with benzodiazepines (very low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.2 [0.55, 2.61]
1 study · 154 participants
Very low

Withdrawals due to adverse events · adults with panic disorder

Antidepressants may leads to higher number of dropouts due to adverse effects compared with benzodiazepines (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.72 [1.03, 2.87]
3 studies · 1002 participants
Low

Withdrawals due to adverse events · adults with panic disorder

TCAs showed no clear difference in number of dropouts due to adverse effects compared with SSRI (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.43 [0.82, 2.48]
5 studies · 476 participants
Low

Withdrawals due to adverse events · adults with panic disorder

SSRIs showed no clear difference in number of dropouts due to adverse effects compared with SNRIs (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.86 [0.49, 7.05]
2 studies · 991 participants
Low