Findings

What do systematic reviews say?

27 questions · 27 findings · 17 reviews

Sort:Best matchNewest Highest certainty Download CSV

No studies found 2 · 7.4%GRADE not reported 1 · 3.7%Very low 8 · 29.6%Low 9 · 33.3%Moderate 7 · 25.9%High 0 · 0%

Intervention not reported

Necrotising enterocolitis · preterm infants with patent ductus arteriosus

The intervention showed no clear difference in necrotising enterocolitis (moderate certainty).

1 finding from 1 review

Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants 2020 · Cochrane Headline outcomes only
RR 1.84 [0.87, 3.9]
2 studies · 264 participants
Moderate

Slow vs faster rates of enteral feed advancement

Necrotising enterocolitis · very preterm or very low birth weight infants

Slow showed no clear difference in necrotising enterocolitis before hospital discharge compared with faster rates of enteral feed advancement (moderate certainty).

1 finding from 1 review

Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants 2021 · Cochrane Headline outcomes only
RR 1.06 [0.83, 1.37]
14 studies · 4026 participants
Moderate

Intervention not reported

Necrotising enterocolitis prior to hospital discharge · very preterm (< 32 weeks' gestation) or very low birth weight (< 1500 g) infants

The intervention may leads to lower necrotising enterocolitis prior to hospital discharge (low certainty).

1 finding from 1 review

Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants 2022 · Cochrane Headline outcomes only
RR 0.81
13 studies · 1507 participants
Low

Intervention not reported

Necrotising enterocolitis (any stage) · preterm infants with patent ductus arteriosus

The intervention may leads to lower necrotising enterocolitis (any stage) (low certainty).

1 finding from 1 review

Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants 2020 · Cochrane Headline outcomes only
RR 0.41 [0.23, 0.73]
7 studies · 249 participants
Low

Intervention not reported

Necrotising enterocolitis (any stage) · preterm infants with patent ductus arteriosus

The intervention probably leads to lower necrotising enterocolitis (any stage) (moderate certainty).

1 finding from 1 review

Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants 2020 · Cochrane Headline outcomes only
RR 0.68 [0.49, 0.94]
18 studies · 1292 participants
Moderate

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids vs single course

Necrotising enterocolitis · the fetus/neonate/infant

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroid showed no clear difference in A11: Necrotising enterocolitis – all fetuses randomised compared with single course (moderate certainty).

1 finding from 1 review

Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes 2022 · Cochrane Headline outcomes only
RR 0.84 [0.59, 1.22]
9 studies · 5736 participants
Moderate

Cervical cerclage in combination with antibiotics and tocolytics vs cervical cerclage

Serious neonatal morbidity

It is very uncertain whether cervical cerclage in combination with antibiotics and tocolytics changes serious neonatal morbidity (Reported in Miller 2014 as 'composite… compared with cervical cerclage alone (very low certainty).

1 finding from 1 review

Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton… 2020 · Cochrane Headline outcomes only
RR 0.62 [0.31, 1.24]
1 study · 50 participants
Very low