Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

74 questions · 80 findings · 28 reviews

No studies found 23 · 28.8%GRADE not reported 0 · 0%Very low 26 · 32.5%Low 26 · 32.5%Moderate 4 · 5%High 1 · 1.3%

Embryo culture with low oxygen concentration vs embryo culture with atmospheric oxygen concentration

Multiple pregnancy rate · Patients with multiple pregnancy rate

Embryo culture with low oxygen concentration showed no clear difference in multiple‐pregnancy rate compared with embryo culture with atmospheric oxygen concentration (low certainty).

1 finding from 1 review

Letrozole with or without adjuncts vs SERMs with or without adjuncts followed by timed intercourse

Multiple pregnancy rate · infertile women with polycystic ovary syndrome

Letrozole with or without adjuncts showed no clear difference in multiple pregnancy rate compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).

1 finding from 1 review

Subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist vs placebo/no treatment

Multiple pregnancy rate · women trying to conceive by intrauterine insemination

It is very uncertain whether subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist changes multiple pregnancy rate compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Human chorionic gonadotropin (hCG) injection vs no treatment

Multiple pregnancy rate · women trying to conceive by intrauterine insemination

It is very uncertain whether human chorionic gonadotropin (hCG) injection changes multiple pregnancy rate compared with no treatment (very low certainty).

1 finding from 1 review