Findings

What do systematic reviews say?

4 questions · 4 findings · 4 reviews · Gynaecology and Fertility

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 25%Low 2 · 50%Moderate 1 · 25%High 0 · 0%

Human chorionic gonadotropin (hCG) injection vs no treatment

Multiple pregnancy rate · women trying to conceive by intrauterine insemination

It is very uncertain whether human chorionic gonadotropin (hCG) injection changes multiple pregnancy rate compared with no treatment (very low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 1.03 [0.22, 4.92]
1 study · 130 participants
Very low

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Multiple pregnancy rate · Women undergoing in vitro fertilisation or intracytoplasmic sperm injection

Day 3 showed no clear difference in multiple pregnancy rate per woman compared with day 2 embryo transfer following IVF or ICSI (moderate certainty).

1 finding from 1 review

Day three versus day two embryo transfer following in vitro fertilization or intracytoplasmic sperm injection 2016 · Cochrane Headline outcomes only
RR 1.12 [0.86, 1.44]
8 studies · 1837 participants
Moderate

GnRHa depot vs GnRHa daily injection

Multiple pregnancy rate · women undergoing pituitary suppression in assisted reproduction

GnRHa depot showed no clear difference in multiple pregnancy rates compared with gnRHa daily injection (low certainty).

1 finding from 1 review

Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down regulation… 2013 · Cochrane Headline outcomes only
OR 1.1 [0.49, 2.46]
4 studies · 132 participants
Low

Assisted hatching vs no assisted hatching

Multiple pregnancy rate · women undergoing assisted reproduction

Assisted hatching may leads to higher multiple pregnancy rate per woman randomised compared with no assisted hatching (low certainty).

1 finding from 1 review

Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI)) 2021 · Cochrane Headline outcomes only
OR 1.38 [1.13, 1.68]
18 studies · 4308 participants
Low