What do systematic reviews say?

Rosuvastatin vs placebo

• Pharmacological interventions for treating heart failure in patients with Chagas cardiomyopathy 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 39 participants
  GRADE not reported

Intervention not reported

The review found no eligible studies for this question.

• Self management interventions for type 2 diabetes in adult people with severe mental illness 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Diet, physical activity, and behavioural interventions for the treatment of overweight or obesity in preschool… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Diet, physical activity, and behavioural interventions for the treatment of overweight or obesity in preschool… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Drug interventions for the treatment of obesity in children and adolescents 2016 · Cochrane Headline outcomes only
  no estimate extracted
  20 studies · 2176 participants
  Moderate

Amiodarone vs other antiarrhythmics

Amiodarone showed no clear difference in all‐cause mortality compared with other antiarrhythmics (low certainty).

• Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
  RR 1.03 [0.75, 1.42]
  5 studies · 898 participants
  Low

Amiodarone vs beta‐blocker

It is very uncertain whether amiodarone changes all‐cause mortality compared with beta blockers (very low certainty).

• Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
  RR 0.96 [0.7, 1.32]
  1 study · 189 participants
  Very low

Amiodarone vs sotalol

It is very uncertain whether amiodarone changes all‐cause mortality compared with sotalol (very low certainty).

• Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
  RR 1.08 [0.41, 2.83]
  2 studies · 104 participants
  Very low

Amiodarone vs placebo or no treatment

Amiodarone showed no clear difference in all‐cause mortality compared with placebo or no treatment (low certainty).

• Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
  RR 0.88 [0.78, 1]
  17 studies · 8383 participants
  Low

Amiodarone vs beta‐blocker

Amiodarone may leads to lower all‐cause mortality compared with beta blockers (low certainty).

• Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
  RR 0.27 [0.1, 0.75]
  2 studies · 342 participants
  Low

Amiodarone vs other antiarrhythmics

Amiodarone probably leads to lower all‐cause mortality compared with other antiarrhythmics (moderate certainty).

• Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
  RR 0.37 [0.18, 0.76]
  3 studies · 540 participants
  Moderate

Amiodarone vs placebo or no treatment

It is very uncertain whether amiodarone changes all‐cause mortality compared with placebo or no treatment (very low certainty).

• Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
  RR 3.05 [1.33, 7.01]
  2 studies · 440 participants
  Very low

Summary of findings: Comparison 3 ‐ deferiprone (DFP) vs deferasirox (DFX)

Summary of findings: Comparison 3 ‐ deferiprone (DFP) showed no clear difference in all‐cause mortality (n/N) compared with deferasirox (DFX) (low certainty).

• Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
  RD 0
  1 study · 390 participants
  Low

Proton pump inhibitors (PPI) vs placebo or no prophylaxis

Proton pump inhibitors showed no clear difference in all‐cause mortality in ICU compared with placebo or no prophylaxis (low certainty).

• Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
  RR 1.09 [0.6, 1.99]
  3 studies · 258 participants
  Low

Antacids vs placebo or no prophylaxis

Antacids showed no clear difference in all‐cause mortality in ICU compared with placebo or no prophylaxis (low certainty).

• Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
  RR 1.01 [0.53, 1.96]
  2 studies · 300 participants
  Low

Sucralfate vs placebo or no prophylaxis

Sucralfate showed no clear difference in all‐cause mortality in ICU compared with placebo or no prophylaxis (low certainty).

• Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
  RR 0.97 [0.66, 1.43]
  5 studies · 500 participants
  Low

H2 receptor antagonists vs proton pump inhibitors

H2 receptor antagonists showed no clear difference in all‐cause mortality in ICU compared with proton pump inhibitors (low certainty).

• Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
  RR 0.96 [0.78, 1.19]
  12 studies · 1564 participants
  Low

H2 receptor antagonists vs antacids

It is very uncertain whether H2 receptor antagonists changes all‐cause mortality in ICU compared with antacids (very low certainty).

• Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
  RR 1.01 [0.66, 1.55]
  11 studies · 1321 participants
  Very low

H2 receptor antagonists vs sucralfate

H2 receptor antagonists showed no clear difference in all‐cause mortality in ICU compared with sucralfate (low certainty).

• Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
  RR 1.09 [0.95, 1.24]
  21 studies · 3178 participants
  Low

Antacids vs sucralfate

Antacids showed no clear difference in all‐cause mortality in ICU compared with sucralfate (low certainty).

• Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
  RR 1.15 [0.93, 1.4]
  11 studies · 1249 participants
  Low