What do systematic reviews say?

Hypertonic saline 7% vs hypertonic saline

The review found no eligible studies for this question.

• Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Saline rinse vs Saline-soaked swab

Saline rinse led to lower mortality compared with saline-soaked swab; GRADE not reported.

• Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia 2020 · Cochrane All outcomes
  RR 0.29 [0.12, 0.69]
  2 studies · 270 participants
  GRADE not reported

Hypertonic saline 3% to 7% vs Normal saline

• Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 142 participants
  Low

Hypertonic saline 3% to 7% vs Normal saline

The review found no eligible studies for this question.

• Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hypertonic saline vs Normal saline

• Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 113 participants
  GRADE not reported

Hypertonic saline vs rhDNase with

The review found no eligible studies for this question.

• Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hypertonic saline vs amiloride

The review found no eligible studies for this question.

• Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hypertonic saline vs sodium‐2‐mercaptoethane sulphonate (Mistabron®)

The review found no eligible studies for this question.

• Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hypertonic saline vs mannitol

The review found no eligible studies for this question.

• Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hypertonic saline 7% vs xylitol

The review found no eligible studies for this question.

• Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Saline rinse vs usual or supportive care

Saline rinse showed no clear difference in mortality compared with usual care (no rinse); GRADE not reported.

• Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia 2020 · Cochrane All outcomes
  RR 1.10 [0.87, 1.39]
  2 studies · 324 participants
  GRADE not reported

Hypertonic saline vs other intracranial pressure‐lowering agents

It is very uncertain whether hypertonic saline changes mortality at 6 months compared with other intracranial pressure‐lowering agents (very low certainty).

• Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury 2020 · Cochrane Headline outcomes only
  RR 0.84 [0.46, 1.55]
  2 studies · 85 participants
  Very low

Hypertonic saline vs other intracranial pressure‐lowering agents

It is very uncertain whether hypertonic saline changes mortality (short‐term) compared with other intracranial pressure‐lowering agents (very low certainty).

• Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury 2020 · Cochrane Headline outcomes only
  RR 0.33
  2 studies · 70 participants
  Very low

Saline vs expectant management

• Umbilical vein injection for management of retained placenta 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 87 participants
  Very low

Heparin vs normal saline solution locking

It is very uncertain whether heparin changes mortality compared with normal saline solution locking (very low certainty).

• Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults 2022 · Cochrane Headline outcomes only
  RR 0.76 [0.44, 1.31]
  3 studies · 1100 participants
  Very low

Povidone iodine rinse vs Saline rinse or placebo

Povidone iodine rinse showed no clear difference in mortality compared with saline rinse or placebo; GRADE not reported.

• Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia 2020 · Cochrane All outcomes
  RR 1.00 [0.66, 1.50]
  2 studies · 217 participants
  GRADE not reported

Magnesium sulphate + epinephrine vs no treatment or normal saline + epinephrine

The review found no eligible studies for this question.

• Magnesium sulphate for treating acute bronchiolitis in children up to two years of age 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Magnesium sulphate vs hypertonic saline

The review found no eligible studies for this question.

• Magnesium sulphate for treating acute bronchiolitis in children up to two years of age 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Balanced crystalloid solutions vs Normal saline

It is very uncertain whether balanced crystalloid solutions changes mortality (during hospitalization) compared with 0.9% saline (very low certainty).

• Balanced crystalloid solutions versus 0.9% saline for treating acute diarrhoea and severe dehydration in children 2023 · Cochrane Headline outcomes only
  RR 0.33 [0.02, 7.39]
  Studies not reported
  Very low

Buffered solutions vs Normal saline

• Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children 2019 · Cochrane Headline outcomes only
  no estimate extracted
  14 studies · 19664 participants
  High