Findings

What do systematic reviews say?

36 questions · 36 findings · 6 reviews · Hepato-Biliary

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No studies found 6 · 16.7%GRADE not reported 0 · 0%Very low 29 · 80.6%Low 1 · 2.8%Moderate 0 · 0%High 0 · 0%

Various interventions vs control

All‐cause mortality · people undergoing laparoscopic cholecystectomy.

1 finding from 1 review

Pharmacological interventions for prevention or treatment of postoperative pain in people undergoing laparoscopic… 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 123 participants
Very low

Ursodeoxycholic acid vs placebo

All‐cause mortality · people with primary sclerosing cholangitis

It is very uncertain whether ursodeoxycholic acid changes mortality compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions for primary sclerosing cholangitis 2017 · Cochrane Headline outcomes only
OR 1.51 [0.63, 3.63]
2 studies · 348 participants
Very low

Antioxidants vs no intervention

All‐cause mortality · people with non‐alcohol‐related fatty liver disease (NAFLD)

1 finding from 1 review

Pharmacological interventions for non‐alcohol related fatty liver disease (NAFLD) 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 87 participants
Very low

Bile acids vs no intervention

Mortality at maximal · people with non‐alcohol‐related fatty liver disease (NAFLD)

It is very uncertain whether bile acids changes mortality at maximal compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for non‐alcohol related fatty liver disease (NAFLD) 2017 · Cochrane Headline outcomes only
OR 5.11 [0.24, 107.34]
4 studies · 659 participants
Very low

Thiazolidinediones vs no intervention

Mortality at maximal · people with non‐alcohol‐related fatty liver disease (NAFLD)

1 finding from 1 review

Pharmacological interventions for non‐alcohol related fatty liver disease (NAFLD) 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 74 participants
Very low

Interferon vs no intervention

Short‐term mortality · people with acute HBV infection

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for acute hepatitis B infection 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Glucocorticosteroids vs no intervention

Mortality at maximal · participants with alcoholic hepatitis (all severity)

It is very uncertain whether glucocorticosteroids changes mortality at maximal compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 0.85 [0.67, 1.08]
12 studies · 1147 participants
Very low

Colchicine vs no intervention

Mortality at maximal · participants with alcoholic hepatitis (all severity)

It is very uncertain whether colchicine changes mortality at maximal compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 1.31 [0.47, 3.64]
2 studies · 139 participants
Very low

Insulin plus glucagon vs no intervention

Mortality at maximal · participants with alcoholic hepatitis (all severity)

It is very uncertain whether insulin plus glucagon changes mortality at maximal compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 1.14 [0.69, 1.9]
5 studies · 265 participants
Very low

Propylthiouracil vs no intervention

Mortality at maximal · participants with alcoholic hepatitis (all severity)

It is very uncertain whether propylthiouracil changes mortality at maximal compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 1.16 [0.5, 2.72]
2 studies · 108 participants
Very low

Glucocorticosteroids vs no intervention

Mortality at maximal · participants with severe alcoholic hepatitis

It is very uncertain whether glucocorticosteroids changes mortality at maximal compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 0.88 [0.63, 1.21]
2 studies · 607 participants
Very low

Pentoxifylline vs no intervention

Mortality at maximal · participants with severe alcoholic hepatitis

It is very uncertain whether pentoxifylline changes mortality at maximal compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 0.8 [0.59, 1.07]
4 studies · 726 participants
Very low

Anabolic steroids vs no intervention

Mortality at maximal · alcohol‐related disorders (others)

It is very uncertain whether anabolic steroids changes mortality at maximal compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 1.29 [0.7, 2.39]
2 studies · 248 participants
Very low

Antioxidants vs no intervention

Mortality at maximal · alcohol‐related disorders (others)

It is very uncertain whether antioxidants changes mortality at maximal compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 1.96 [0.99, 3.89]
2 studies · 255 participants
Very low

Colchicine vs no intervention

Mortality at maximal · alcohol‐related disorders (others)

It is very uncertain whether colchicine changes mortality at maximal compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 1.11 [0.8, 1.53]
2 studies · 604 participants
Very low

Propylthiouracil vs no intervention

Mortality at maximal · alcohol‐related disorders (others)

Propylthiouracil may leads to lower mortality at maximal compared with no intervention (low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 0.45 [0.26, 0.78]
2 studies · 423 participants
Low

Pentoxifylline vs no intervention

Mortality at maximal · participants with alcoholic hepatitis (all severity)

It is very uncertain whether pentoxifylline changes mortality at maximal compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 0.77 [0.58, 1.02]
6 studies · 881 participants
Very low

Ursodeoxycholic acid vs no intervention

Mortality at maximal · people with primary biliary cholangitis

It is very uncertain whether ursodeoxycholic acid (UDCA) changes mortality at maximal compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for primary biliary cholangitis 2017 · Cochrane Headline outcomes only
OR 0.99 [0.6, 1.64]
6 studies · 734 participants
Very low

Ciclosporin vs no intervention

Mortality at maximal · people with primary biliary cholangitis

It is very uncertain whether ciclosporin changes mortality at maximal compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for primary biliary cholangitis 2017 · Cochrane Headline outcomes only
OR 0.88 [0.51, 1.5]
3 studies · 390 participants
Very low

D‐Penicillamine vs no intervention

Mortality at maximal · people with primary biliary cholangitis

It is very uncertain whether D‐Penicillamine changes mortality at maximal compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for primary biliary cholangitis 2017 · Cochrane Headline outcomes only
OR 0.9 [0.57, 1.44]
5 studies · 423 participants
Very low