Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

90 questions · 94 findings · 28 reviews

No studies found 32 · 34%GRADE not reported 7 · 7.4%Very low 21 · 22.3%Low 22 · 23.4%Moderate 12 · 12.8%High 0 · 0%

Lidocaine vs mexiletine

All‐cause mortality · patients with myocardial infarction

It is very uncertain whether lidocaine changes all‐cause mortality compared with mexiletine (very low certainty).

1 finding from 1 review

Lidocaine vs disopyramide

All‐cause mortality · patients with myocardial infarction

It is very uncertain whether lidocaine changes all‐cause mortality compared with disopyramide (very low certainty).

1 finding from 1 review

Antibiotics vs placebo

All‐cause mortality WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in all‐cause mortality WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Vitamin K antagonist (VKA) prophylaxis vs no prophylaxis

Mortality at 6 months: main analysis · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Vitamin K antagonist (VKA) prophylaxis showed no clear difference in mortality at 6 months: main analysis compared with no prophylaxis (moderate certainty).

1 finding from 1 review