What do systematic reviews say?

DFP and DFO vs deferoxamine

The review found no eligible studies for this question.

• Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: Comparison 3 ‐ deferiprone (DFP) vs deferasirox (DFX)

Summary of findings: Comparison 3 ‐ deferiprone (DFP) showed no clear difference in all‐cause mortality (n/N) compared with deferasirox (DFX) (low certainty).

• Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
  RD 0
  1 study · 390 participants
  Low

One uterine devascularisation technique (uterine arterial embolisation) vs another uterine devascularisation technique (surgical devascularisation plus B‐Lynch)

The review found no eligible studies for this question.

• Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

DFP and DFO vs DFP and DFX

It is very uncertain whether summary of findings: Comparison 7 ‐ deferiprone (DFP) plus… changes all‐cause mortality ‐ at 1 year ‐ trial end compared with DFP plus deferasirox (DFX) (very low certainty).

• Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
  RD 0
  1 study · 96 participants
  Very low

Lipid‐lowering agent vs placebo or no treatment

Lipid‐lowering agent showed no clear difference in stroke‐related mortality (only reported for one study: CT scan, MRI… compared with placebo or no treatment (low certainty).

• Pharmacological interventions for asymptomatic carotid stenosis 2023 · Cochrane Headline outcomes only
  RR 0.25 [0.03, 2.29]
  2 studies · 1366 participants
  Low

Very low vs low protein diet

The review found no eligible studies for this question.

• Dietary interventions for mineral and bone disorder in people with chronic kidney disease 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Low phosphorus vs normal diet

The review found no eligible studies for this question.

• Dietary interventions for mineral and bone disorder in people with chronic kidney disease 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Post‐haemodialysis dietary supplement vs normal diet

The review found no eligible studies for this question.

• Dietary interventions for mineral and bone disorder in people with chronic kidney disease 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Low phosphorus intake (avoiding food additives) vs normal diet

Low phosphorus intake (avoiding food additives) showed no clear difference in mortality compared with normal diet (moderate certainty).

• Dietary interventions for mineral and bone disorder in people with chronic kidney disease 2015 · Cochrane Headline outcomes only
  RR 0.18 [0.01, 3.82]
  1 study · 279 participants
  Moderate

Low phosphorus intake plus placebo vs ad libitum diet plus placebo

The review found no eligible studies for this question.

• Dietary interventions for mineral and bone disorder in people with chronic kidney disease 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Low phosphorus intake plus lanthanum carbonate vs ad libitum diet plus lanthanum carbonate

The review found no eligible studies for this question.

• Dietary interventions for mineral and bone disorder in people with chronic kidney disease 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Calcium‐enriched bread vs calcium acetate

The review found no eligible studies for this question.

• Dietary interventions for mineral and bone disorder in people with chronic kidney disease 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intravenous tranexamic acid vs placebo

Intravenous tranexamic acid showed no clear difference in all‐cause mortality (30 days post‐surgery) compared with placebo (low certainty).

• Pharmacological interventions for the prevention of bleeding in people undergoing definitive fixation or joint… 2023 · Cochrane Headline outcomes only
  Peto OR 0.38 [0.05, 2.77]
  2 studies · 147 participants
  Low

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs placebo

It is very uncertain whether topical tranexamic acid changes all‐cause mortality (30 days post‐surgery) compared with placebo (very low certainty).

• Pharmacological interventions for the prevention of bleeding in people undergoing definitive fixation or joint… 2023 · Cochrane Headline outcomes only
  RD 0
  1 study · 36 participants
  Very low

Surgery plus radiotherapy vs Radiotherapy alone

It is very uncertain whether surgery plus radiotherapy changes total mortality compared with radiotherapy alone (very low certainty).

• Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes

  3 years
  HR 0.24 [0.10, 0.59]
  1 study · 35 participants
  Very low

Surgery vs Radiotherapy alone

Surgery showed no clear difference in total mortality compared with radiotherapy alone (low certainty).

• Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes

  3 years
  HR 0.83 [0.09, 7.46]
  1 study · 68 participants
  Low

Pre-operative radiotherapy (plus surgery) vs surgery

Pre-operative radiotherapy (plus surgery) showed no clear difference in total mortality compared with surgery alone; GRADE not reported.

• Interventions for the treatment of oral cavity and oropharyngeal cancer: radiotherapy 2010 · Cochrane All outcomes
  HR 0.83 [0.64, 1.07]
  1 study
  GRADE not reported

Pre-operative and post-operative radiotherapy vs Post-operative radiotherapy alone

Pre-operative and post-operative radiotherapy showed no clear difference in total mortality compared with post-operative radiotherapy alone; GRADE not reported.

• Interventions for the treatment of oral cavity and oropharyngeal cancer: radiotherapy 2010 · Cochrane All outcomes
  HR 0.67 [0.35, 1.28]
  1 study
  GRADE not reported

Clobetasol propionate cream vs prednisone

Clobetasol propionate cream showed no clear difference in mortality at 1 year compared with oral prednisone (low certainty).

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  RR 0.73 [0.53, 1.01]
  1 study · 341 participants
  Low

Deferasirox vs deferiprone (DFO)

• Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
  0.96 [0.06, 15.42]
  2 studies · 240 participants
  Very low