Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

398 questions · 434 findings · 166 reviews

No studies found 95 · 21.9%GRADE not reported 31 · 7.1%Very low 91 · 21%Low 110 · 25.3%Moderate 78 · 18%High 29 · 6.7%

Low‐dose computed tomography (LDCT) screening vs no LDCT screening

Mortality: lung cancer · healthy adults

Low‐dose computed tomography (LDCT) screening probably leads to lower lung cancer‐related mortality ‐ planned time points compared with no LDCT screening (moderate certainty).

1 finding from 1 review

Lower total dose radiotherapy (67.2 Gy over 5.6 weeks) vs conventional dose RT

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Lower total dose radiotherapy (67.2 Gy over 5.6 weeks) showed no clear difference in total mortality compared with conventional/standard total dose radiotherapy (72 Gy); GRADE not reported.

1 finding from 1 review

PET-CT following chemoradiotherapy (neck dissection only if no/incomplete response) vs Planned neck dissection before or after chemoradiotherapy

Total mortality · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)

PET-CT following chemoradiotherapy (neck dissection only if… showed no clear difference in total mortality compared with planned neck dissection before or after chemoradiotherapy (moderate certainty).

1 finding from 1 review

Lower blood pressure targets vs standard blood pressure targets

Cardiovascular mortality · cardiovascular disease with high blood pressure

Lower blood pressure targets showed no clear difference in cardiovascular mortality compared with standard blood pressure targets (moderate certainty).

1 finding from 1 review

Low molecular weight heparin vs active control

1‐year overall mortality · ambulatory cancer patients receiving chemotherapy

The review found no eligible studies for this question.

3 findings from 1 review

Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels

Mortality before hospital discharge · health problem or population

It is very uncertain whether summary of Findings Table ‐ Low changes mortality, by hospital discharge compared with moderate‐high nasal continuous positive airway pressure levels (very low certainty).

2 findings from 1 review

Low‐dose opioid based general anaesthesia vs high‐dose opioid based general anaesthesia

Mortality ‐ Death at any time after surgery · adult cardiac surgical patients

Low‐dose opioid‐based GA showed no clear difference in mortality ‐ Death at any time after surgery compared with high‐dose opioid‐based GA (low certainty).

1 finding from 1 review

Low molecular weight heparin vs vitamin K antagonist (VKA)

All‐cause mortality (up to 3 months) · people with cancer with thrombosis prophylaxis and central venous catheters

Low‐molecular‐weight heparin (LMWH) showed no clear difference in all‐cause mortality (up to 3 months) compared with vitamin K antagonist (VKA) (low certainty).

1 finding from 1 review